PDF(Pubmed)
Abstract：
OBJECTIVE: This meta-analysis aims to analyze the relationship between serum vitamin D (VD) levels and Graves\' disease (GD).
METHODS: We conducted a search for publications on VD and GD in the English language. Our search encompassed databases such as PubMed, Embase, Web of Science, and the Cochrane Library, covering publications available through August 2023. A meta-analysis was performed using Cochrane RevMan 5.4 software. The standardized mean difference (SMD) and 95% confidence interval (CI) were used for outcome calculation. We used R software to test for publication bias.
RESULTS: Twelve studies were selected, comprising 937 (22.4%) cases with GD and 3254 (77.6%) controls. The overall meta-analysis revealed that patients with GD are significantly more likely to have low VD levels (SMD = - 0.66; 95% CI: -1.05, - 0.27; p = 0.001) than those in the control group. Egger\'s test results indicated no publication bias (p = 0.0791). These studies exhibited a high degree of heterogeneity (chi-square = 205.86, p < 0.00001; I2 = 95%). Subgroup analysis was conducted based on assay method, geographic location, and mean age of the case group to explore the heterogeneity sources. Assay methods and geographic locations were identified as potential heterogeneity sources. Based on the mean age, there were no statistically significant differences found in the subgroup analysis of the included studies.
CONCLUSIONS: There is promising evidence that low serum VD levels may increase the risk of GD. Further rigorous and long-term trials are needed to explore the role of VD in the onset and treatment of GD.
METHODS: We conducted a search for publications on VD and GD in the English language. Our search encompassed databases such as PubMed, Embase, Web of Science, and the Cochrane Library, covering publications available through August 2023. A meta-analysis was performed using Cochrane RevMan 5.4 software. The standardized mean difference (SMD) and 95% confidence interval (CI) were used for outcome calculation. We used R software to test for publication bias.
RESULTS: Twelve studies were selected, comprising 937 (22.4%) cases with GD and 3254 (77.6%) controls. The overall meta-analysis revealed that patients with GD are significantly more likely to have low VD levels (SMD = - 0.66; 95% CI: -1.05, - 0.27; p = 0.001) than those in the control group. Egger\'s test results indicated no publication bias (p = 0.0791). These studies exhibited a high degree of heterogeneity (chi-square = 205.86, p < 0.00001; I2 = 95%). Subgroup analysis was conducted based on assay method, geographic location, and mean age of the case group to explore the heterogeneity sources. Assay methods and geographic locations were identified as potential heterogeneity sources. Based on the mean age, there were no statistically significant differences found in the subgroup analysis of the included studies.
CONCLUSIONS: There is promising evidence that low serum VD levels may increase the risk of GD. Further rigorous and long-term trials are needed to explore the role of VD in the onset and treatment of GD.
摘要：
目的：本荟萃分析旨在分析血清维生素D（VD）水平与Graves病（GD）之间的关系。
方法：我们搜索了有关VD和GD的英文出版物。我们的搜索包括PubMed等数据库，Embase,WebofScience,还有Cochrane图书馆,涵盖2023年8月之前可用的出版物。使用CochraneRevMan5.4软件进行荟萃分析。结果计算采用标准化平均差(SMD)和95%置信区间(CI)。我们使用R软件来测试发表偏倚。
结果：选择了12项研究，包括937例（22.4%）GD和3254例（77.6%）对照。总体荟萃分析显示，与对照组相比，GD患者更有可能患有低VD水平（SMD=-0.66；95％CI：-1.05，-0.27；p=0.001）。Egger的测试结果表明没有发表偏倚（p=0.0791）。这些研究表现出高度的异质性(卡方=205.86,p<0.00001;I2=95%)。根据测定方法进行亚组分析，地理位置,和病例组的平均年龄来探索异质性来源。测定方法和地理位置被确定为潜在的异质性来源。根据平均年龄，在纳入研究的亚组分析中没有发现统计学上的显著差异.
结论：有证据表明低血清VD水平可能增加GD的风险。需要进一步严格和长期的试验来探索VD在GD发病和治疗中的作用。
方法：我们搜索了有关VD和GD的英文出版物。我们的搜索包括PubMed等数据库，Embase,WebofScience,还有Cochrane图书馆,涵盖2023年8月之前可用的出版物。使用CochraneRevMan5.4软件进行荟萃分析。结果计算采用标准化平均差(SMD)和95%置信区间(CI)。我们使用R软件来测试发表偏倚。
结果：选择了12项研究，包括937例（22.4%）GD和3254例（77.6%）对照。总体荟萃分析显示，与对照组相比，GD患者更有可能患有低VD水平（SMD=-0.66；95％CI：-1.05，-0.27；p=0.001）。Egger的测试结果表明没有发表偏倚（p=0.0791）。这些研究表现出高度的异质性(卡方=205.86,p<0.00001;I2=95%)。根据测定方法进行亚组分析，地理位置,和病例组的平均年龄来探索异质性来源。测定方法和地理位置被确定为潜在的异质性来源。根据平均年龄，在纳入研究的亚组分析中没有发现统计学上的显著差异.
结论：有证据表明低血清VD水平可能增加GD的风险。需要进一步严格和长期的试验来探索VD在GD发病和治疗中的作用。
