METHODS: A cohort of patients with SAIDs treated at a high-complexity center in Cali (southwestern Colombia) with follow-up from January 2008 to December 2022 were examined to search for potential AEs associated with prolonged use of RTX.
RESULTS: From 178 patients with long-term use of RTX 3 (1.68%) had lymphadenopathies with lymphoid follicular hyperplasia related to BAFF overexpression, 4 (2.24%) with bronchiectasis, and 4 (2.24%) with lymphoplasmacytic cystitis.
CONCLUSIONS: Bronchiectasis, lymphoid follicular hyperplasia related to BAFF overexpression, and lymphoplasmacytic cystitis may be life-threatening long-term AEs in patients with prolonged use of RTX.
方法:对2008年1月至2022年12月在卡利(哥伦比亚西南部)的高复杂性中心接受治疗的SAIDs患者进行了队列检查,以寻找与长期使用RTX相关的潜在不良事件。
结果:从长期使用RTX3的178例患者(1.68%)出现与BAFF过度表达相关的淋巴滤泡增生,4例(2.24%)支气管扩张,淋巴浆细胞性膀胱炎4例(2.24%)。
结论:支气管扩张,与BAFF过表达有关的淋巴滤泡增生,对于长期使用RTX的患者,淋巴浆细胞性膀胱炎可能是危及生命的长期不良事件.