Abstract：
BACKGROUND: The long-term use of rituximab (RTX) has been gaining ground in the treatment of systemic autoimmune diseases. The adverse events (AEs) associated with its use different to infections are being reported.
METHODS: A cohort of patients with SAIDs treated at a high-complexity center in Cali (southwestern Colombia) with follow-up from January 2008 to December 2022 were examined to search for potential AEs associated with prolonged use of RTX.
RESULTS: From 178 patients with long-term use of RTX 3 (1.68%) had lymphadenopathies with lymphoid follicular hyperplasia related to BAFF overexpression, 4 (2.24%) with bronchiectasis, and 4 (2.24%) with lymphoplasmacytic cystitis.
CONCLUSIONS: Bronchiectasis, lymphoid follicular hyperplasia related to BAFF overexpression, and lymphoplasmacytic cystitis may be life-threatening long-term AEs in patients with prolonged use of RTX.
METHODS: A cohort of patients with SAIDs treated at a high-complexity center in Cali (southwestern Colombia) with follow-up from January 2008 to December 2022 were examined to search for potential AEs associated with prolonged use of RTX.
RESULTS: From 178 patients with long-term use of RTX 3 (1.68%) had lymphadenopathies with lymphoid follicular hyperplasia related to BAFF overexpression, 4 (2.24%) with bronchiectasis, and 4 (2.24%) with lymphoplasmacytic cystitis.
CONCLUSIONS: Bronchiectasis, lymphoid follicular hyperplasia related to BAFF overexpression, and lymphoplasmacytic cystitis may be life-threatening long-term AEs in patients with prolonged use of RTX.
摘要：
背景：长期使用利妥昔单抗（RTX）已在治疗全身性自身免疫性疾病方面取得了进展。报告了与感染不同的不良事件（AE）。
方法：对2008年1月至2022年12月在卡利（哥伦比亚西南部）的高复杂性中心接受治疗的SAIDs患者进行了队列检查，以寻找与长期使用RTX相关的潜在不良事件。
结果：从长期使用RTX3的178例患者（1.68％）出现与BAFF过度表达相关的淋巴滤泡增生，4例（2.24%）支气管扩张，淋巴浆细胞性膀胱炎4例（2.24%）。
结论：支气管扩张，与BAFF过表达有关的淋巴滤泡增生，对于长期使用RTX的患者,淋巴浆细胞性膀胱炎可能是危及生命的长期不良事件.
方法：对2008年1月至2022年12月在卡利（哥伦比亚西南部）的高复杂性中心接受治疗的SAIDs患者进行了队列检查，以寻找与长期使用RTX相关的潜在不良事件。
结果：从长期使用RTX3的178例患者（1.68％）出现与BAFF过度表达相关的淋巴滤泡增生，4例（2.24%）支气管扩张，淋巴浆细胞性膀胱炎4例（2.24%）。
结论：支气管扩张，与BAFF过表达有关的淋巴滤泡增生，对于长期使用RTX的患者,淋巴浆细胞性膀胱炎可能是危及生命的长期不良事件.
