PDF(Pubmed)
Abstract：
UNASSIGNED: Dementia with Lewy bodies (DLB) presents with various symptoms, posing challenges for early diagnosis challenging. Dopamine transporter (123I-FP-CIT) single-photon emission tomography (SPECT) and 123I-meta-iodobenzylguanidine (123I-MIBG) imaging are crucial diagnostic biomarkers. Hypothesis about body- and brain-first subtypes of DLB indicate that some DLB may show normal 123I-FP-CIT or 123I-MIBG results; but the characteristic expression of these two subtypes remains unclear.
UNASSIGNED: This study aimed to evaluate the diagnostic sensitivity of 123I-FP-CIT and 123I-MIBG imaging alone, combined in patients with DLB and explore symptoms associated with the abnormal imaging results.
UNASSIGNED: Demographic data, clinical status, and imaging results were retrospectively collected from patients diagnosed with possible DLB. Both images were quantified using semi-automated software, and the sensitivity of each imaging modality and their combination was calculated. Demographic data, cognition, and motor and non-motor symptoms were compared among the subgroups based on the imaging results. Symptoms related to each imaging abnormality were examined using binomial logistic regression analyses.
UNASSIGNED: Among 114 patients with DLB, 80 underwent 123I-FP-CIT SPECT (sensitivity: 80.3%), 83 underwent 123I-MIBG imaging (68.2%), and 66 both (sensitivity of either abnormal result: 93.9%). Visual hallucinations differed among the four subgroups based on imaging results. Additionally, nocturia and orthostatic hypotension differed between abnormal and normal 123I-MIBG images.
UNASSIGNED: Overall, 123I-FP-CIT SPECT was slightly higher sensitivity than 123I-MIBG imaging, with combined imaging increasing diagnostic sensitivity. Normal results of a single imaging test may not refute DLB. Autonomic symptoms may lead to abnormal 123I-MIBG scintigraphy findings indicating body-first subtype of patients with DLB.
UNASSIGNED: This study aimed to evaluate the diagnostic sensitivity of 123I-FP-CIT and 123I-MIBG imaging alone, combined in patients with DLB and explore symptoms associated with the abnormal imaging results.
UNASSIGNED: Demographic data, clinical status, and imaging results were retrospectively collected from patients diagnosed with possible DLB. Both images were quantified using semi-automated software, and the sensitivity of each imaging modality and their combination was calculated. Demographic data, cognition, and motor and non-motor symptoms were compared among the subgroups based on the imaging results. Symptoms related to each imaging abnormality were examined using binomial logistic regression analyses.
UNASSIGNED: Among 114 patients with DLB, 80 underwent 123I-FP-CIT SPECT (sensitivity: 80.3%), 83 underwent 123I-MIBG imaging (68.2%), and 66 both (sensitivity of either abnormal result: 93.9%). Visual hallucinations differed among the four subgroups based on imaging results. Additionally, nocturia and orthostatic hypotension differed between abnormal and normal 123I-MIBG images.
UNASSIGNED: Overall, 123I-FP-CIT SPECT was slightly higher sensitivity than 123I-MIBG imaging, with combined imaging increasing diagnostic sensitivity. Normal results of a single imaging test may not refute DLB. Autonomic symptoms may lead to abnormal 123I-MIBG scintigraphy findings indicating body-first subtype of patients with DLB.
摘要：
■路易体痴呆（DLB）表现出各种症状，对早期诊断提出挑战。多巴胺转运蛋白（123I-FP-CIT）单光子发射断层扫描（SPECT）和123I-间碘苄基胍（123I-MIBG）成像是重要的诊断生物标志物。关于DLB的身体和大脑优先亚型的假设表明，某些DLB可能显示正常的123I-FP-CIT或123I-MIBG结果；但是这两种亚型的特征性表达尚不清楚。
■本研究旨在评估单独使用123I-FP-CIT和123I-MIBG成像的诊断敏感性，结合DLB患者的影像学检查结果，探讨与异常相关的症状。
■人口统计数据，临床状态，回顾性收集诊断可能患有DLB的患者的影像学结果.两幅图像都使用半自动软件进行了量化，并计算每种成像模式及其组合的灵敏度。人口统计数据,认知，根据影像学结果比较各亚组之间的运动和非运动症状.使用二项逻辑回归分析检查与每种影像学异常相关的症状。
■在114名DLB患者中，80例接受123I-FP-CITSPECT（灵敏度：80.3%），83例接受了123I-MIBG成像（68.2%），和66（任一异常结果的敏感性：93.9%）。根据成像结果，四个亚组之间的视觉幻觉有所不同。此外,夜尿症和直立性低血压在异常和正常的123I-MIBG图像之间存在差异。
■总的来说，123I-FP-CITSPECT的灵敏度略高于123I-MIBG成像，联合成像提高了诊断灵敏度。单个成像测试的正常结果可能无法反驳DLB。自主症状可能导致异常的123I-MIBG闪烁显像结果，表明DLB患者的身体第一亚型。
■本研究旨在评估单独使用123I-FP-CIT和123I-MIBG成像的诊断敏感性，结合DLB患者的影像学检查结果，探讨与异常相关的症状。
■人口统计数据，临床状态，回顾性收集诊断可能患有DLB的患者的影像学结果.两幅图像都使用半自动软件进行了量化，并计算每种成像模式及其组合的灵敏度。人口统计数据,认知，根据影像学结果比较各亚组之间的运动和非运动症状.使用二项逻辑回归分析检查与每种影像学异常相关的症状。
■在114名DLB患者中，80例接受123I-FP-CITSPECT（灵敏度：80.3%），83例接受了123I-MIBG成像（68.2%），和66（任一异常结果的敏感性：93.9%）。根据成像结果，四个亚组之间的视觉幻觉有所不同。此外,夜尿症和直立性低血压在异常和正常的123I-MIBG图像之间存在差异。
■总的来说，123I-FP-CITSPECT的灵敏度略高于123I-MIBG成像，联合成像提高了诊断灵敏度。单个成像测试的正常结果可能无法反驳DLB。自主症状可能导致异常的123I-MIBG闪烁显像结果，表明DLB患者的身体第一亚型。
