APOA5 在 PIK3CA 突变的结直肠癌中减轻活性氧以促进奥沙利铂耐药。
关键词: PIK3CA mutation apolipoprotein A5 colorectal cancer oxaliplatin resistance reactive oxygen species
Mesh : Humans Colorectal Neoplasms / genetics drug therapy metabolism Drug Resistance, Neoplasm / genetics Apolipoprotein A-V / genetics metabolism Oxaliplatin / pharmacology therapeutic use Reactive Oxygen Species / metabolism Class I Phosphatidylinositol 3-Kinases / genetics metabolism Mutation Animals Cell Line, Tumor Antineoplastic Agents / pharmacology therapeutic use Mice Male Apoptosis / drug effects genetics Sterol Regulatory Element Binding Protein 1 / genetics metabolism Female Gene Expression Regulation, Neoplastic / drug effects Signal Transduction / drug effects
来 源:
DOI:10.18632/aging.205872
PDF(Pubmed)