PDF(Pubmed)
Abstract：
UNASSIGNED: Coronary artery calcification (CAC) has been established as an independent risk factor for major adverse cardiovascular events. Nevertheless, the effect of CAC on in-hospital mortality and adverse clinical outcomes in patients with COVID-19 has yet to be determined.
UNASSIGNED: To investigate the association between CAC score and in-hospital mortality of COVID-19 patients.
UNASSIGNED: This retrospective cohort study was conducted across tertiary hospitals of University of Medical Sciences in Babol, a northern city in Iran, and enroled 551 confirmed COVID-19 patients with definitive clinical outcomes of death or discharge between March and October 2021. Demographic and clinical data, along with chest computed tomography (CT) findings and CAC score on admission, were systematically collected. The study utilized logistic regression analysis and Kaplan-Meier plots to explore the association between CAC score and in-hospital death and adverse clinical outcomes.
UNASSIGNED: The mean age was 60.05±12.8. A significant difference regarding CAC score, age, history of hypertension, hyperlipidemia, cardiovascular diseases, and respiratory diseases among survivors and non-survivors was observed; however, gender was not found to be different. Furthermore, in multivariate analysis, CAC score greater than or equal to 400 [odds ratio (OR): 4.2, 95% CI: 1.70-10.33, P value: 0.002], hospitalization time (OR: 1.31, 95% CI: 1.13-1.53, P value < 0.001), length of ICU stay (OR: 2.02, 95% CI: 1.47-2.77, P value < 0.001), severe or critical COVID-19 severity in time of admission (95% CI: 1.79-18.29, P value: 0.003), and history of respiratory diseases (95% CI: 2.18-40, P value: 0.003) were found to be associated with higher odds of in-hospital mortality. Log-rank test also revealed a significant difference regarding the time of admission to death between patients with CAC score greater than or equal to 400 and those with CAC score less than 400 (P value < 0.001).
UNASSIGNED: Elevated CAC score is a crucial risk factor linked to in-hospital mortality and unfavourable clinical results in confirmed COVID-19 patients. This finding emphasizes the need for careful monitoring of individuals with high CAC scores.
UNASSIGNED: To investigate the association between CAC score and in-hospital mortality of COVID-19 patients.
UNASSIGNED: This retrospective cohort study was conducted across tertiary hospitals of University of Medical Sciences in Babol, a northern city in Iran, and enroled 551 confirmed COVID-19 patients with definitive clinical outcomes of death or discharge between March and October 2021. Demographic and clinical data, along with chest computed tomography (CT) findings and CAC score on admission, were systematically collected. The study utilized logistic regression analysis and Kaplan-Meier plots to explore the association between CAC score and in-hospital death and adverse clinical outcomes.
UNASSIGNED: The mean age was 60.05±12.8. A significant difference regarding CAC score, age, history of hypertension, hyperlipidemia, cardiovascular diseases, and respiratory diseases among survivors and non-survivors was observed; however, gender was not found to be different. Furthermore, in multivariate analysis, CAC score greater than or equal to 400 [odds ratio (OR): 4.2, 95% CI: 1.70-10.33, P value: 0.002], hospitalization time (OR: 1.31, 95% CI: 1.13-1.53, P value < 0.001), length of ICU stay (OR: 2.02, 95% CI: 1.47-2.77, P value < 0.001), severe or critical COVID-19 severity in time of admission (95% CI: 1.79-18.29, P value: 0.003), and history of respiratory diseases (95% CI: 2.18-40, P value: 0.003) were found to be associated with higher odds of in-hospital mortality. Log-rank test also revealed a significant difference regarding the time of admission to death between patients with CAC score greater than or equal to 400 and those with CAC score less than 400 (P value < 0.001).
UNASSIGNED: Elevated CAC score is a crucial risk factor linked to in-hospital mortality and unfavourable clinical results in confirmed COVID-19 patients. This finding emphasizes the need for careful monitoring of individuals with high CAC scores.
摘要：
■冠状动脉钙化（CAC）已被确定为主要不良心血管事件的独立危险因素。然而，CAC对COVID-19患者院内死亡率和不良临床结局的影响尚待确定.
■探讨CAC评分与COVID-19患者住院死亡率之间的关系。
这项回顾性队列研究是在巴博尔医科大学的三级医院进行的，伊朗北部城市,在2021年3月至10月期间，551例确诊的COVID-19患者的临床结局为死亡或出院。人口统计学和临床数据，以及入院时的胸部计算机断层扫描（CT）发现和CAC评分，被系统地收集。该研究利用逻辑回归分析和Kaplan-Meier图来探索CAC评分与住院死亡和不良临床结局之间的关联。
■平均年龄为60.05±12.8。关于CAC评分的显著差异，年龄,高血压病史,高脂血症,心血管疾病,观察到幸存者和非幸存者中的呼吸系统疾病；然而，没有发现性别不同。此外，在多变量分析中，CAC得分大于或等于400[优势比（OR）：4.2，95％CI：1.70-10.33，P值：0.002]，住院时间(OR:1.31,95%CI:1.13-1.53,P值<0.001),ICU住院时间(OR:2.02,95%CI:1.47-2.77,P值<0.001),入院时严重或严重的COVID-19严重程度（95％CI：1.79-18.29，P值：0.003），研究发现,呼吸系统疾病病史(95%CI:2.18-40,P值:0.003)与住院死亡率的几率较高相关.Log-rank检验还显示，CAC评分大于或等于400的患者与CAC评分小于400的患者之间的入院死亡时间存在显着差异（P值<0.001）。
■在确诊的COVID-19患者中，CAC评分升高是与院内死亡率和不良临床结果相关的关键风险因素。这一发现强调了对CAC得分高的个体进行仔细监测的必要性。
■探讨CAC评分与COVID-19患者住院死亡率之间的关系。
这项回顾性队列研究是在巴博尔医科大学的三级医院进行的，伊朗北部城市,在2021年3月至10月期间，551例确诊的COVID-19患者的临床结局为死亡或出院。人口统计学和临床数据，以及入院时的胸部计算机断层扫描（CT）发现和CAC评分，被系统地收集。该研究利用逻辑回归分析和Kaplan-Meier图来探索CAC评分与住院死亡和不良临床结局之间的关联。
■平均年龄为60.05±12.8。关于CAC评分的显著差异，年龄,高血压病史,高脂血症,心血管疾病,观察到幸存者和非幸存者中的呼吸系统疾病；然而，没有发现性别不同。此外，在多变量分析中，CAC得分大于或等于400[优势比（OR）：4.2，95％CI：1.70-10.33，P值：0.002]，住院时间(OR:1.31,95%CI:1.13-1.53,P值<0.001),ICU住院时间(OR:2.02,95%CI:1.47-2.77,P值<0.001),入院时严重或严重的COVID-19严重程度（95％CI：1.79-18.29，P值：0.003），研究发现,呼吸系统疾病病史(95%CI:2.18-40,P值:0.003)与住院死亡率的几率较高相关.Log-rank检验还显示，CAC评分大于或等于400的患者与CAC评分小于400的患者之间的入院死亡时间存在显着差异（P值<0.001）。
■在确诊的COVID-19患者中，CAC评分升高是与院内死亡率和不良临床结果相关的关键风险因素。这一发现强调了对CAC得分高的个体进行仔细监测的必要性。
