PDF(Pubmed)
Abstract：
UNASSIGNED: Breast cancer (BC) represents a significant health challenge in Europe due to its elevated prevalence and heterogeneity. Despite notable progress in diagnostic and treatment methods, the region continues to grapple with rising BC burdens, with comprehensive investigations into this matter notably lacking. This study explores BC burden and potential contributing risk factors in 44 European countries from 1990 to 2019. The aim is to furnish evidence supporting the development of strategies for managing BC effectively.
UNASSIGNED: Disease burden estimates related to breast cancer from the Global Burden of Disease 2019(GBD2019) across Eastern, Central, and Western Europe were examined using Joinpoint regression for trends from 1990 to 2019. Linear regression models examined relationships between BC burden and Socio-demographic Index (SDI), healthcare access and quality (HAQ), and BC prevalence. We utilized disability-adjusted life year(DALY) proportions for each risk factor to depict BC risks.
UNASSIGNED: In Europe, the BC burden was 463.2 cases per 100,000 people in 2019, 1.7 times the global burden. BC burden in women was significantly higher and increased with age. Age-standardized mortality and DALY rates of BC in Europe in 2019 decreased by 23.1%(average annual percent change: AAPC -0.92) and 25.9%(AAPC -1.02), respectively, compared to 1990, in line with global trends. From 1990 to 2019, age-standardized DALY declined faster in Western Europe (-34.8%, AAPC -1.49) than in Eastern Europe (-9.4%, AAPC -0.25) and Central Europe (-15.0%, AAPC -0.56). Monaco, Serbia, and Montenegro had the highest BC burden in Europe in 2019. BC burden was negatively correlated with HAQ. In addition, Alcohol use and Tobacco were significant risk factors for DALY. High fasting plasma glucose and obesity were also crucial risk factors that cannot be ignored in DALY.
UNASSIGNED: The burden of BC in Europe remains a significant health challenge, with regional variations despite an overall downward trend. Addressing the burden of BC in different regions of Europe and the increase of DALY caused by different risk factors, targeted prevention measures should be taken, especially the management of alcohol and tobacco should be strengthened, and screening services for BC should be popularized, and medical resources and technology allocation should be optimized.
UNASSIGNED: Disease burden estimates related to breast cancer from the Global Burden of Disease 2019(GBD2019) across Eastern, Central, and Western Europe were examined using Joinpoint regression for trends from 1990 to 2019. Linear regression models examined relationships between BC burden and Socio-demographic Index (SDI), healthcare access and quality (HAQ), and BC prevalence. We utilized disability-adjusted life year(DALY) proportions for each risk factor to depict BC risks.
UNASSIGNED: In Europe, the BC burden was 463.2 cases per 100,000 people in 2019, 1.7 times the global burden. BC burden in women was significantly higher and increased with age. Age-standardized mortality and DALY rates of BC in Europe in 2019 decreased by 23.1%(average annual percent change: AAPC -0.92) and 25.9%(AAPC -1.02), respectively, compared to 1990, in line with global trends. From 1990 to 2019, age-standardized DALY declined faster in Western Europe (-34.8%, AAPC -1.49) than in Eastern Europe (-9.4%, AAPC -0.25) and Central Europe (-15.0%, AAPC -0.56). Monaco, Serbia, and Montenegro had the highest BC burden in Europe in 2019. BC burden was negatively correlated with HAQ. In addition, Alcohol use and Tobacco were significant risk factors for DALY. High fasting plasma glucose and obesity were also crucial risk factors that cannot be ignored in DALY.
UNASSIGNED: The burden of BC in Europe remains a significant health challenge, with regional variations despite an overall downward trend. Addressing the burden of BC in different regions of Europe and the increase of DALY caused by different risk factors, targeted prevention measures should be taken, especially the management of alcohol and tobacco should be strengthened, and screening services for BC should be popularized, and medical resources and technology allocation should be optimized.
摘要：
■由于其患病率和异质性的升高，乳腺癌（BC）在欧洲代表了重大的健康挑战。尽管在诊断和治疗方法方面取得了显著进展，该地区继续努力应对不断上升的不列颠哥伦比亚省负担，对此事的全面调查尤其缺乏。这项研究探讨了1990年至2019年44个欧洲国家的BC负担和潜在的危险因素。目的是提供证据支持制定有效管理BC的战略。
■来自东部地区2019年全球疾病负担（GBD2019）的与乳腺癌相关的疾病负担估计中央,和西欧使用Joinpoint回归检查了1990年至2019年的趋势。线性回归模型检验了BC负担与社会人口指数(SDI)之间的关系，医疗保健准入和质量(HAQ)，和BC患病率。我们利用残疾调整生命年(DALY)比例来描述每个风险因素的BC风险。
■在欧洲，2019年，不列颠哥伦比亚省的负担为每10万人463.2例，是全球负担的1.7倍。女性的BC负担显着升高，并且随着年龄的增长而增加。2019年欧洲不列颠哥伦比亚省的年龄标准化死亡率和DALY率分别下降了23.1%（年均百分比变化：AAPC-0.92）和25.9%（AAPC-1.02），分别,与1990年相比，符合全球趋势。从1990年到2019年，西欧的年龄标准化DALY下降更快(-34.8%，AAPC-1.49）比东欧（-9.4％，AAPC-0.25）和中欧（-15.0%，AAPC-0.56）。摩纳哥,塞尔维亚,黑山在2019年是欧洲公元前负担最高的国家。BC负荷与HAQ呈负相关。此外,饮酒和吸烟是DALY的重要危险因素。高空腹血糖和肥胖也是DALY不可忽视的重要危险因素。
■不列颠哥伦比亚省在欧洲的负担仍然是一个重大的健康挑战，尽管总体呈下降趋势，但区域差异很大。解决不列颠哥伦比亚省在欧洲不同地区的负担和不同风险因素导致的DALY增加，应采取有针对性的预防措施，特别是加强烟酒管理,应该普及BC的筛查服务，优化医疗资源和技术配置。
■来自东部地区2019年全球疾病负担（GBD2019）的与乳腺癌相关的疾病负担估计中央,和西欧使用Joinpoint回归检查了1990年至2019年的趋势。线性回归模型检验了BC负担与社会人口指数(SDI)之间的关系，医疗保健准入和质量(HAQ)，和BC患病率。我们利用残疾调整生命年(DALY)比例来描述每个风险因素的BC风险。
■在欧洲，2019年，不列颠哥伦比亚省的负担为每10万人463.2例，是全球负担的1.7倍。女性的BC负担显着升高，并且随着年龄的增长而增加。2019年欧洲不列颠哥伦比亚省的年龄标准化死亡率和DALY率分别下降了23.1%（年均百分比变化：AAPC-0.92）和25.9%（AAPC-1.02），分别,与1990年相比，符合全球趋势。从1990年到2019年，西欧的年龄标准化DALY下降更快(-34.8%，AAPC-1.49）比东欧（-9.4％，AAPC-0.25）和中欧（-15.0%，AAPC-0.56）。摩纳哥,塞尔维亚,黑山在2019年是欧洲公元前负担最高的国家。BC负荷与HAQ呈负相关。此外,饮酒和吸烟是DALY的重要危险因素。高空腹血糖和肥胖也是DALY不可忽视的重要危险因素。
■不列颠哥伦比亚省在欧洲的负担仍然是一个重大的健康挑战，尽管总体呈下降趋势，但区域差异很大。解决不列颠哥伦比亚省在欧洲不同地区的负担和不同风险因素导致的DALY增加，应采取有针对性的预防措施，特别是加强烟酒管理,应该普及BC的筛查服务，优化医疗资源和技术配置。
