PDF(Pubmed)
Abstract：
A 47-year-old woman developed severe kidney dysfunction after taking a lipid-lowering supplement, Red Yeast Rice Cholestehelp, for approximately 7 months. The patient developed sudden nausea and had an elevated serum creatinine level of 4.26 mg/dL. A kidney biopsy showed findings consistent with acute tubular necrosis. Kidney dysfunction improved with discontinuation of supplementation, and corticosteroid therapy. Similar kidney involvement has been reported, raising concerns regarding supplements in Japan. An investigation of the nephrotoxic ingredients in the same product batches is currently underway. This report underscores the need for public awareness and warnings of health risk concerns associated with unregulated supplements.
摘要：
一名47岁女性服用降脂补充剂后出现严重肾功能不全,红酵母米饭cholestehelp，大约7个月。患者突然出现恶心，血清肌酐水平升高，为4.26mg/dL。肾活检显示与急性肾小管坏死一致。肾功能障碍随着补充的停止而改善，和皮质类固醇治疗。据报道类似的肾脏受累，引起人们对日本补充剂的担忧。目前正在对同一批次产品中的肾毒性成分进行调查。该报告强调了公众对与不受监管的补充剂相关的健康风险问题的认识和警告的必要性。
