PDF(Pubmed)
Abstract：
BACKGROUND: Women with polycystic ovary syndrome (PCOS) are usually selected to undergo an ovulation induction regimen or a programmed regimen for endometrial preparation in the frozen-thawed embryo transfer (FET) during their IVF/ICSI treatment. The programmed regimen permits flexible scheduling of embryo transfer but requires long-term usage of exogenous estrogen and higher dosages of luteal support while the letrozole ovulation regimen needs lower dosages of luteal support only. Recently, multiple studies have shown that the letrozole ovulation regimen can improve pregnancy outcomes of FET in women with PCOS compared with the programmed regimen. However, most of these studies are retrospective, and prospective studies are urgently needed the evidence from the perspective study is insufficient.
METHODS: We are undertaking a multicentre, randomized, controlled clinical trial of an endometrial preparation regimen for FET in women with PCOS. The eligible women are randomly assigned to either the letrozole ovulation regimen or the programmed regimen for endometrial preparation. The primary outcome is the clinical pregnancy rate.
CONCLUSIONS: The results of this study will provide evidence for whether the letrozole ovulation regimen for endometrial preparation could improve pregnancy outcomes in PCOS women undergoing FET.
BACKGROUND: Chinese Clinical Trial Registry ChiCTR2200062244. Registered on 31 July 2022.
METHODS: We are undertaking a multicentre, randomized, controlled clinical trial of an endometrial preparation regimen for FET in women with PCOS. The eligible women are randomly assigned to either the letrozole ovulation regimen or the programmed regimen for endometrial preparation. The primary outcome is the clinical pregnancy rate.
CONCLUSIONS: The results of this study will provide evidence for whether the letrozole ovulation regimen for endometrial preparation could improve pregnancy outcomes in PCOS women undergoing FET.
BACKGROUND: Chinese Clinical Trial Registry ChiCTR2200062244. Registered on 31 July 2022.
摘要：
背景：患有多囊卵巢综合征（PCOS）的妇女通常被选择在IVF/ICSI治疗期间接受促排卵方案或在冻融胚胎移植（FET）中进行子宫内膜准备的程序化方案。程序化的方案允许灵活地安排胚胎移植，但需要长期使用外源性雌激素和更高剂量的黄体支持，而来曲唑排卵方案仅需要较低剂量的黄体支持。最近,多项研究表明,与程序化方案相比,来曲唑排卵方案可改善PCOS患者FET的妊娠结局.然而,这些研究大多是回顾性的，和前瞻性研究是迫切需要的，从角度研究的证据是不够的。
方法：我们正在进行多中心，随机化，PCOS女性子宫内膜准备FET方案的对照临床试验。符合条件的妇女被随机分配到来曲唑排卵方案或子宫内膜准备的程序化方案。主要结果是临床妊娠率。
结论：本研究结果将为子宫内膜准备来曲唑排卵方案是否可以改善接受FET的PCOS妇女的妊娠结局提供证据。
背景：中国临床试验注册ChiCTR2200062244。2022年7月31日注册。
方法：我们正在进行多中心，随机化，PCOS女性子宫内膜准备FET方案的对照临床试验。符合条件的妇女被随机分配到来曲唑排卵方案或子宫内膜准备的程序化方案。主要结果是临床妊娠率。
结论：本研究结果将为子宫内膜准备来曲唑排卵方案是否可以改善接受FET的PCOS妇女的妊娠结局提供证据。
背景：中国临床试验注册ChiCTR2200062244。2022年7月31日注册。
