Abstract：
OBJECTIVE: To examine the association between cerebral artery stenosis and depressive symptoms in elderly patients.
METHODS: The study participants were 365 patients aged ≥65 years who visited the psychiatric outpatient clinic, Samsung Medical Center between January 1, 2000, and December 31, 2019, and were diagnosed with depressive disorder. They had brain imaging tests including magnetic resonance angiography (MRA), psychological evaluations including the 15-item Geriatric Depression Scale (GDS-15), and lab tests. Individuals\' cerebral artery stenosis was identified and the association with significant depressive symptoms was examined.
RESULTS: Of the 365 subjects, 108 had at least one location of cerebral artery stenosis (29.6 %). The mean score of GDS-15 in the stenosis group was 8.1 (SD, 3.8), higher than the mean GDS-15 score of 6.5 (SD, 4.0) for the group without stenosis (p < 0.001). Compared to no middle cerebral artery (MCA) stenosis, having MCA stenosis was associated with significant depressive symptoms (p = 0.005). Compared to no posterior cerebral artery (PCA) stenosis, having left PCA stenosis was associated with significant depressive symptoms (p = 0.022). In the multivariable linear regression analysis, only bilateral MCA stenosis had a positive association with the score of GDS-15 (p = 0.013).
CONCLUSIONS: Bilateral MCA stenosis and left PCA stenosis are associated with significant depressive symptoms among elderly patients, with bilateral MCA stenosis positively associated with the severity of depression.
METHODS: The study participants were 365 patients aged ≥65 years who visited the psychiatric outpatient clinic, Samsung Medical Center between January 1, 2000, and December 31, 2019, and were diagnosed with depressive disorder. They had brain imaging tests including magnetic resonance angiography (MRA), psychological evaluations including the 15-item Geriatric Depression Scale (GDS-15), and lab tests. Individuals\' cerebral artery stenosis was identified and the association with significant depressive symptoms was examined.
RESULTS: Of the 365 subjects, 108 had at least one location of cerebral artery stenosis (29.6 %). The mean score of GDS-15 in the stenosis group was 8.1 (SD, 3.8), higher than the mean GDS-15 score of 6.5 (SD, 4.0) for the group without stenosis (p < 0.001). Compared to no middle cerebral artery (MCA) stenosis, having MCA stenosis was associated with significant depressive symptoms (p = 0.005). Compared to no posterior cerebral artery (PCA) stenosis, having left PCA stenosis was associated with significant depressive symptoms (p = 0.022). In the multivariable linear regression analysis, only bilateral MCA stenosis had a positive association with the score of GDS-15 (p = 0.013).
CONCLUSIONS: Bilateral MCA stenosis and left PCA stenosis are associated with significant depressive symptoms among elderly patients, with bilateral MCA stenosis positively associated with the severity of depression.
摘要：
目的：探讨老年患者脑动脉狭窄与抑郁症状的关系。
方法：研究参与者是365名年龄≥65岁的患者，他们在精神科门诊就诊，三星医疗中心于2000年1月1日至2019年12月31日期间被诊断患有抑郁症。他们进行了脑部成像检查，包括磁共振血管造影（MRA），心理评估，包括15项老年抑郁量表（GDS-15），和实验室测试。确定了个体的脑动脉狭窄，并检查了与显着抑郁症状的关联。
结果：在365名受试者中，108例患者至少有一处脑动脉狭窄（29.6%）。狭窄组GDS-15的平均得分为8.1（SD，3.8),高于平均GDS-15评分6.5(SD，4.0）适用于无狭窄组（p<0.001）。与无大脑中动脉（MCA）狭窄相比，MCA狭窄与显著的抑郁症状相关(p=0.005)。与没有大脑后动脉（PCA）狭窄相比，左PCA狭窄与显著的抑郁症状相关(p=0.022).在多元线性回归分析中，只有双侧MCA狭窄与GDS-15评分呈正相关(p=0.013).
结论：双侧MCA狭窄和左侧PCA狭窄与老年患者的抑郁症状有关，双侧MCA狭窄与抑郁的严重程度呈正相关。
方法：研究参与者是365名年龄≥65岁的患者，他们在精神科门诊就诊，三星医疗中心于2000年1月1日至2019年12月31日期间被诊断患有抑郁症。他们进行了脑部成像检查，包括磁共振血管造影（MRA），心理评估，包括15项老年抑郁量表（GDS-15），和实验室测试。确定了个体的脑动脉狭窄，并检查了与显着抑郁症状的关联。
结果：在365名受试者中，108例患者至少有一处脑动脉狭窄（29.6%）。狭窄组GDS-15的平均得分为8.1（SD，3.8),高于平均GDS-15评分6.5(SD，4.0）适用于无狭窄组（p<0.001）。与无大脑中动脉（MCA）狭窄相比，MCA狭窄与显著的抑郁症状相关(p=0.005)。与没有大脑后动脉（PCA）狭窄相比，左PCA狭窄与显著的抑郁症状相关(p=0.022).在多元线性回归分析中，只有双侧MCA狭窄与GDS-15评分呈正相关(p=0.013).
结论：双侧MCA狭窄和左侧PCA狭窄与老年患者的抑郁症状有关，双侧MCA狭窄与抑郁的严重程度呈正相关。
