PDF(Pubmed)
Abstract：
Genes strictly regulate the development of teeth and their surrounding oral structures. Alteration of gene regulation leads to tooth disorders and developmental anomalies in tooth, oral, and facial regions. With the advancement of gene sequencing technology, genomic data is rapidly increasing. However, the large sets of genomic and proteomic data related to tooth development and dental disorders are currently dispersed in many primary databases and literature, making it difficult for users to navigate, extract, study, or analyze. We have curated the scattered genetic data on tooth development and created a knowledgebase called \'Bioinformatics for Dentistry\' (https://dentalbioinformatics.com/). This database compiles genomic and proteomic data on human tooth development and developmental anomalies and organizes them according to their roles in different stages of tooth development. The database is built by systemically curating relevant data from the National Library of Medicine (NCBI) GenBank, OMIM: Online Mendelian Inheritance in Man, AlphaFold Protein Structure Database, Reactome pathway knowledgebase, Wiki Pathways, and PubMed. The accuracy of the included data was verified from supporting primary literature. Upon data curation and validation, a simple, easy-to-navigate browser interface was created on WordPress version 6.3.2, with PHP version 8.0. The website is hosted in a cloud hosting service to provide fast and reliable data transfer rate. Plugins are used to ensure the browser\'s compatibility across different devices. Bioinformatics for Dentistry contains four embedded filters for complex and specific searches and free-text search options for quick and simple searching through the datasets. Bioinformatics for Dentistry is made freely available worldwide, with the hope that this knowledgebase will improve our understanding of the complex genetic regulation of tooth development and will open doors to research initiatives and discoveries. This database will be expanded in the future by incorporating resources and built-in sequence analysis tools, and it will be maintained and updated annually.
摘要：
基因严格调节牙齿及其周围口腔结构的发育。基因调控的改变导致牙齿疾病和牙齿发育异常，口服,和面部区域。随着基因测序技术的进步,基因组数据正在迅速增加。然而,与牙齿发育和牙齿疾病相关的大量基因组和蛋白质组数据目前分散在许多主要数据库和文献中，使用户难以导航，Extract,study,或分析。我们整理了有关牙齿发育的分散遗传数据，并创建了一个名为“牙科生物信息学”的知识库（https://dentalbioinformatics.com/）。该数据库汇编了人类牙齿发育和发育异常的基因组和蛋白质组数据，并根据它们在牙齿发育的不同阶段的作用进行组织。该数据库是通过系统地整理来自国家医学图书馆（NCBI）GenBank的相关数据来构建的，OMIM：在线孟德尔人继承，AlphaFold蛋白质结构数据库,反应组通路知识库，Wiki途径,和PubMed。从支持的主要文献中验证了所包含数据的准确性。在数据管理和验证后，一个简单的，易于导航的浏览器界面是在WordPress版本6.3.2上创建的，PHP版本8.0。该网站托管在云托管服务中，以提供快速可靠的数据传输速率。插件用于确保浏览器在不同设备之间的兼容性。牙科生物信息学包含四个用于复杂和特定搜索的嵌入式过滤器，以及用于快速和简单搜索数据集的自由文本搜索选项。牙科生物信息学在全球范围内免费提供，希望这个知识库将提高我们对牙齿发育的复杂遗传调控的理解，并为研究计划和发现打开大门。未来将通过整合资源和内置序列分析工具来扩展该数据库，它将每年维护和更新。
