METHODS: A total of 112 patients with gestational hypertension disease were divided into two groups: early-onset preeclampsia (32 cases) and late-onset preeclampsia (80 cases). A control group of 82 normotensive pregnant women matched for age and parity was also selected. Blood samples were collected from all participants to test for specific hematologic parameters.
RESULTS: Mild and severe preeclampsia were associated with lower hemoglobin level (P = 0.01 and P = 0.03, respectively), higher mean platelet volume (P = 0.01 and P = 0.01, respectively) and fibrinogen (P = 0.01 and P = 0.01, respectively), and shorter prothrombin time (P = 0.02 and P = 0.01, respectively) and activated partial thromboplastin time (P = 0.01 and P = 0.02, respectively).
CONCLUSIONS: These findings have provided evidence on the hematologic coagulative actors in the pathogenesis and severity of preeclampsia.
方法:112例妊娠期高血压疾病患者分为早发型子痫前期(32例)和晚发型子痫前期(80例)。还选择了82名年龄和胎次相匹配的正常血压孕妇的对照组。从所有参与者收集血样以测试特定的血液学参数。
结果:轻度和重度子痫前期与较低的血红蛋白水平有关(分别为P=0.01和P=0.03),较高的平均血小板体积(分别为P=0.01和P=0.01)和纤维蛋白原(分别为P=0.01和P=0.01),和更短的凝血酶原时间(分别为P=0.02和P=0.01)和活化部分凝血活酶时间(分别为P=0.01和P=0.02)。
结论:这些发现为子痫前期的发病机制和严重程度中的血液凝血因子提供了证据。