PDF(Pubmed)
Abstract：
A 32-year-old man with sickle cell disease (SCD) was admitted to the hospital for sickle cell crisis, during which laboratory workup revealed primary hyperparathyroidism. His treatment regimen included hydration, calcitonin, and calcimimetics. A parathyroid nuclear scan revealed anomalous parathyroid tissue. The precise relationship between primary hyperparathyroidism (PHPT) and SCD remains incompletely understood but may involve factors such as vitamin D deficiency, elevated erythropoietin levels, and the influence of growth factors on the development of parathyroid adenomas. Furthermore, the concurrent occurrence of both PHPT and SCD at an earlier age may potentiate adverse long-term outcomes. Effective management of PHPT in SCD entails addressing hypercalcemia and treating the underlying cause of hyperparathyroidism. While a potential association between PHPT and SCD exists, further research is essential to better elucidate their interaction, prevalence, clinical presentations, and outcomes.
摘要：
一名患有镰状细胞病(SCD)的32岁男子因镰状细胞危象入院,实验室检查显示原发性甲状旁腺功能亢进。他的治疗方案包括补水,降钙素,和拟钙剂。甲状旁腺核扫描显示异常甲状旁腺组织。原发性甲状旁腺功能亢进（PHPT）和SCD之间的确切关系仍未完全了解，但可能涉及维生素D缺乏等因素。促红细胞生成素水平升高，以及生长因子对甲状旁腺腺瘤发生发展的影响。此外，在较早年龄同时发生PHPT和SCD可能会增强长期不良结局.SCD中PHPT的有效管理需要解决高钙血症和治疗甲状旁腺功能亢进的根本原因。虽然PHPT和SCD之间存在潜在关联，进一步的研究对于更好地阐明它们的相互作用至关重要，患病率,临床表现,和结果。
