PDF(Pubmed)
Abstract：
The objective of this study was to investigate the prevalence of vitamin D deficiency or insufficiency and its association with inflammatory markers and type 2 diabetes. We conducted our research at Qingdao Endocrine and Diabetes Hospital, where serum 25-hydroxyvitamin D3 levels were determined for 2,806 individuals with type 2 diabetes aged 30 and older between January 2018 and December 2019. Medical records were analyzed, and data on health, blood lipids, HbA1c, and inflammation were collected. Our results revealed a high prevalence of vitamin D deficiency in the population. Among male and female patients, median serum 25(OH)D3 levels were 22.46 and 19.00 ng/mL, respectively. More than 60% of female patients had vitamin D deficiency, with over 80% having levels below 30 ng/mL. We observed a favorable connection between high-density lipoprotein cholesterol and 25(OH)D3, while triglycerides and HbA1c showed negative correlations. As 25(OH)D3 levels increased, inflammatory markers such as hypersensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), white blood cell count, neutrophil count, and monocyte count decreased (trend test, p < 0.05), although peripheral blood lymphocytes initially increased and then decreased. After controlling for age and gender, multiple linear regression analysis indicated negative correlations between ESR, hsCRP, and white blood cell count with 25(OH)D3 (p < 0.05). In conclusion, our study demonstrates that individuals with type 2 diabetes often exhibit vitamin D deficiency or insufficiency, which is associated with elevated levels of inflammatory markers in the blood.
摘要：
这项研究的目的是调查维生素D缺乏或不足的患病率及其与炎症标志物和2型糖尿病的关系。我们在青岛内分泌糖尿病医院进行了研究，在2018年1月至2019年12月期间,对2,806名年龄在30岁及以上的2型糖尿病患者进行了血清25-羟基维生素D3水平测定.分析了医疗记录，和健康数据，血脂,HbA1c,并收集炎症。我们的结果表明，人群中维生素D缺乏的患病率很高。在男性和女性患者中，中位血清25（OH）D3水平为22.46和19.00ng/mL，分别。超过60%的女性患者有维生素D缺乏,超过80％的水平低于30ng/mL。我们观察到高密度脂蛋白胆固醇与25（OH）D3之间存在良好的联系，而甘油三酸酯与HbA1c呈负相关。随着25(OH)D3水平的增加，炎症标志物，如超敏C反应蛋白（hsCRP），红细胞沉降率（ESR），白细胞计数,中性粒细胞计数,单核细胞计数下降(趋势检验，p<0.05)，尽管外周血淋巴细胞最初增加，然后减少。在控制了年龄和性别之后，多元线性回归分析表明，ESR之间呈负相关，hsCRP,和25(OH)D3的白细胞计数(p<0.05)。总之,我们的研究表明，2型糖尿病患者经常表现出维生素D缺乏或不足，这与血液中炎症标志物水平升高有关。
