Abstract：
<b>Background and Objective:</b> Urinary tract infections from the use of an indwelling urinary catheter are one of the most common infections caused by <i>Proteus mirabilis</i>. Due to their biofilm-producing capacity and the increasing antimicrobial resistance in this microorganism, this study aimed to determine the prevalence, biofilm-producing capacity, antimicrobial resistance patterns, multidrug resistance and plasmid mediated resistance of the recovered isolates. <b>Materials and Methods:</b> A total of 50 urinary samples were collected from May to August, 2018 from patients on indwelling urinary catheters. Using routine microbiological and biochemical methods, 37 <i>P. mirabilis</i> were isolated. Biofilm forming capability was determined among the isolates using the tube method while antimicrobial susceptibility and plasmid curing were also performed. <b>Results:</b> All isolates were biofilm producers with 17(46%) being moderate producers while 20(54%) were strong biofilm formers. The study isolates exhibited a high resistance rate to empiric antibiotics, including ceftazidime (75.8%), cefuroxime (54.5%), ampicillin (69.7%) and amoxicillin-clavulanic acid (51.5%). Low resistance was seen in the fluoroquinolones, gentamicin and nitrofurantoin. Plasmid curing experiment revealed that most isolates lost their resistance indicating that resistance was borne on plasmids. Plasmid carriage is likely the reason for the high MDR rate of 56.8% observed. <b>Conclusion:</b> These findings necessitate the provision of infection control programs which will guide and implement policies.
摘要：
<b>背景和目的:</b>使用留置导尿管引起的尿路感染是<i>变形杆菌</i>引起的最常见感染之一。由于它们的生物膜产生能力和这种微生物的抗菌素抗性增加，这项研究旨在确定患病率，生物膜生产能力，抗菌素耐药性模式，回收分离株的多药耐药性和质粒介导的耐药性。<b>材料和方法:</b>从5月到8月共采集了50个尿样本,2018年患者留置导尿管。使用常规的微生物和生化方法，37<i>P奇迹</i>被隔离。使用试管法确定分离物中的生物膜形成能力，同时还进行了抗微生物剂敏感性和质粒固化。＆lt;b＆gt;结果：＆lt;/b＆gt;所有分离株均为生物膜生产者，其中17个（46％）为中度生产者，而20个（54％）为强生物膜形成者。研究分离株对经验性抗生素表现出很高的耐药率，包括头孢他啶(75.8%)，头孢呋辛（54.5%），氨苄西林（69.7％）和阿莫西林-克拉维酸（51.5％）。氟喹诺酮类药物的耐药性低，庆大霉素和呋喃妥因。质粒固化实验表明，大多数分离株失去了抗性，表明抗性是在质粒上产生的。质粒携带可能是观察到的56.8%的高MDR率的原因。<b>结论:</b>这些发现需要提供感染控制方案来指导和实施政策。
