Abstract：
Chemistry has the power to endow supramolecular nanostructures with new biomedically relevant functions. Here it is reported that DNA nanostructures modified with cholesterol tags disrupt bacterial membranes to cause microbial cell death. The lipidated DNA nanostructures bind more readily to cholesterol-free bacterial membranes than to cholesterol-rich, eukaryotic membranes. These highly negatively charged, lipidated DNA nanostructures cause bacterial cell death by rupturing membranes. Strikingly, killing is mediated by clusters of barrel-shaped nanostructures that adhere to the membrane without the involvement of expected bilayer-puncturing barrels. These DNA nanomaterials may inspire the development of polymeric or small-molecule antibacterial agents that mimic the principles of selective binding and rupturing to help combat antimicrobial resistance.
摘要：
化学有能力赋予超分子纳米结构新的生物医学相关功能。这里报道了用胆固醇标签修饰的DNA纳米结构破坏细菌膜导致微生物细胞死亡。与富含胆固醇的细菌膜相比，脂化的DNA纳米结构更容易与无胆固醇的细菌膜结合。真核细胞膜。这些带高度负电荷的，脂化的DNA纳米结构通过破裂膜导致细菌细胞死亡。引人注目的是，杀死是由粘附在膜上的桶状纳米结构簇介导的，而没有预期的双层穿刺桶的参与。这些DNA纳米材料可能会激发聚合物或小分子抗菌剂的发展，这些抗菌剂模仿选择性结合和破裂的原理，以帮助对抗抗微生物耐药性。
