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Abstract：
BACKGROUND: Laparoscopic sleeve gastrectomy combined with fundoplication (LSGFD) can significantly control body weight and achieve effective anti-reflux effects. The aim of this study is to investigate the correlation between the alteration in Ghrelin levels and weight loss following SGFD, and to compare Ghrelin levels, weight loss and metabolic improvements between SG and SGFD, with the objective of contributing to the existing body of knowledge on SGFD technique in the management of patients with obesity and gastroesophageal reflux disease (GERD).
METHODS: A retrospective analysis was conducted on the clinical data of 115 obese patients who underwent bariatric surgery between March 2023 and June 2023 at the Department of Minimally Invasivew Surgery, Hernia and Abdominal Wall Surgery, People\'s Hospital of Xinjiang Uygur Autonomous Region. The subjects were divided into two groups based on surgical methods: sleeve gastrectomy group (SG group, 93 cases) and sleeve gastrectomy combined with fundoplication group (SGFD group, 22 cases). Clinical data, such as ghrelin levels before and after the operation, were compared between the two groups, and the correlation between changes in ghrelin levels and weight loss effectiveness after the operation was analyzed.
RESULTS: Three months after the operation, there was no significant difference in body mass, BMI, EWL%, fasting blood glucose, triglyceride, cholesterol, and uric acid levels between the SG and SGFD groups (P > 0.05). However, the SGFD group exhibited a significant decrease in body weight, BMI, and uric acid levels compared to preoperative levels (P < 0.05), while the decrease in ghrelin levels was not statistically significant (P > 0.05). Logistic regression analysis indicated that ghrelin levels three months after the operation were influential in postoperative weight loss.
CONCLUSIONS: The reduction of plasma Ghrelin level in patients after SGFD is not as obvious as that in patients after SG, but it can make obese patients get the same good weight loss and metabolic improvement as patients after SG. Ghrelin level at the third month after operation is the influencing factor of postoperative weight loss.
METHODS: A retrospective analysis was conducted on the clinical data of 115 obese patients who underwent bariatric surgery between March 2023 and June 2023 at the Department of Minimally Invasivew Surgery, Hernia and Abdominal Wall Surgery, People\'s Hospital of Xinjiang Uygur Autonomous Region. The subjects were divided into two groups based on surgical methods: sleeve gastrectomy group (SG group, 93 cases) and sleeve gastrectomy combined with fundoplication group (SGFD group, 22 cases). Clinical data, such as ghrelin levels before and after the operation, were compared between the two groups, and the correlation between changes in ghrelin levels and weight loss effectiveness after the operation was analyzed.
RESULTS: Three months after the operation, there was no significant difference in body mass, BMI, EWL%, fasting blood glucose, triglyceride, cholesterol, and uric acid levels between the SG and SGFD groups (P > 0.05). However, the SGFD group exhibited a significant decrease in body weight, BMI, and uric acid levels compared to preoperative levels (P < 0.05), while the decrease in ghrelin levels was not statistically significant (P > 0.05). Logistic regression analysis indicated that ghrelin levels three months after the operation were influential in postoperative weight loss.
CONCLUSIONS: The reduction of plasma Ghrelin level in patients after SGFD is not as obvious as that in patients after SG, but it can make obese patients get the same good weight loss and metabolic improvement as patients after SG. Ghrelin level at the third month after operation is the influencing factor of postoperative weight loss.
摘要：
背景：腹腔镜袖状胃切除术联合胃底折叠术（LSGFD）可以显着控制体重并实现有效的抗反流作用。这项研究的目的是调查Ghrelin水平的改变与SGFD后体重减轻之间的相关性。为了比较Ghrelin水平，SG和SGFD之间的体重减轻和代谢改善，目的是为肥胖和胃食管反流病（GERD）患者的治疗提供有关SGFD技术的现有知识。
方法：对2023年3月至2023年6月在微创外科接受减肥手术的115例肥胖患者的临床资料进行了回顾性分析，疝和腹壁手术,新疆维吾尔自治区人民医院.根据手术方法将受试者分为两组:袖状胃切除术组(SG组,93例)和袖状胃切除术联合胃底折叠术组(SGFD组,22例)。临床数据,例如手术前后的ghrelin水平，两组比较,分析ghrelin水平变化与术后减肥效果的相关性。
结果：术后3个月，体重没有显着差异，BMI,EWL%,空腹血糖,甘油三酯，胆固醇,SG组和SGFD组之间的尿酸水平(P>0.05)。然而,SGFD组显示体重显著下降，BMI,和尿酸水平与术前相比（P<0.05），而ghrelin水平下降无统计学意义(P>0.05)。Logistic回归分析显示，术后3个月ghrelin水平对术后体重减轻有影响。
结论：SGFD后患者血浆Ghrelin水平的降低不如SG后患者明显，但它可以使肥胖患者获得与SG后患者相同的良好体重减轻和代谢改善。术后第3个月Ghrelin水平是术后体重减轻的影响因素。
方法：对2023年3月至2023年6月在微创外科接受减肥手术的115例肥胖患者的临床资料进行了回顾性分析，疝和腹壁手术,新疆维吾尔自治区人民医院.根据手术方法将受试者分为两组:袖状胃切除术组(SG组,93例)和袖状胃切除术联合胃底折叠术组(SGFD组,22例)。临床数据,例如手术前后的ghrelin水平，两组比较,分析ghrelin水平变化与术后减肥效果的相关性。
结果：术后3个月，体重没有显着差异，BMI,EWL%,空腹血糖,甘油三酯，胆固醇,SG组和SGFD组之间的尿酸水平(P>0.05)。然而,SGFD组显示体重显著下降，BMI,和尿酸水平与术前相比（P<0.05），而ghrelin水平下降无统计学意义(P>0.05)。Logistic回归分析显示，术后3个月ghrelin水平对术后体重减轻有影响。
结论：SGFD后患者血浆Ghrelin水平的降低不如SG后患者明显，但它可以使肥胖患者获得与SG后患者相同的良好体重减轻和代谢改善。术后第3个月Ghrelin水平是术后体重减轻的影响因素。
