Abstract:
Impaired insulin secretory capacity is associated with high glycemic variability in patients with type 2 diabetes (T2DM). However, there are no existing reports on the association between insulin secretory capacity and time in range (TIR). This retrospective study involved 330 T2DM admitted for diabetes education who underwent intermittently scanned continuous glucose monitoring (isCGM) and had their fasting serum C-peptide immunoreactivity (S-CPR) measured within 5 days of admission. The baseline characteristics were as follows: age, 60.2 years; glycated hemoglobin (HbA1c), 9.2%; S-CPR, 2.2 ng/mL; S-CPR index (S-CPR [ng/mL]/fasting plasma glucose [mg/dL] × 100), 1.6; and TIR, 60.3%. TIR correlated significantly with the S-CPR index, which was confirmed by multivariate analysis that included various factors such as HbA1c. Receiver operating characteristic (ROC) analysis showed that 1.88 was the optimal S-CPR index level to predict TIR ≥ 70%. In addition to HbA1c and biguanide use, the S-CPR index was a significant factor associated with TIR > 70%. S-CPR index values of ≥ 1.88 also correlated significantly with TIR > 70%. In conclusion, insulin secretory capacity is associated with TIR in Japanese T2DM, suggesting that the S-CPR index might be a potentially useful biomarker insulin secretory capacity, in association with TIR.Trial registration UMIN0000254333.
摘要:
2型糖尿病(T2DM)患者的胰岛素分泌能力受损与高血糖变异性相关。然而,目前尚无关于胰岛素分泌能力与作用时间(TIR)之间关联的报道.这项回顾性研究涉及330名接受糖尿病教育的T2DM,他们接受了间歇性扫描连续血糖监测(isCGM),并在入院后5天内测量了其空腹血清C肽免疫反应性(S-CPR)。基线特征如下:年龄,60.2岁;糖化血红蛋白(HbA1c),9.2%;S-CPR,2.2ng/mL;S-CPR指数(S-CPR[ng/mL]/空腹血糖[mg/dL]×100),1.6;和TIR,60.3%。TIR与S-CPR指数显著相关,这通过包括HbA1c等各种因素的多变量分析得到证实。接收器工作特性(ROC)分析表明,1.88是预测TIR≥70%的最佳S-CPR指数水平。除了HbA1c和双胍的使用,S-CPR指数是与TIR>70%相关的重要因素.S-CPR指数值≥1.88也与TIR>70%显著相关。总之,胰岛素分泌能力与日本T2DM的TIR有关,这表明S-CPR指数可能是一个潜在有用的生物标志物胰岛素分泌能力,与TIR相关。试用注册UMIN0000254333。