PDF(Pubmed)
Abstract：
Sex bias is known in the prevalence/pathology of neurodevelopmental disorders. Sex-dependent differences of the certain brain areas are known to emerge perinatally through the exposure to sex hormones, while gene expression patterns in the rodent embryonic brain does not seem to be completely the same between male and female. To investigate potential sex differences in gene expression and cortical organization during the embryonic period in mice, we conducted a comprehensive analysis of gene expression for the telencephalon at embryonic day (E) 11.5 (a peak of neural stem cell expansion) and E14.5 (a peak of neurogenesis) using bulk RNA-seq data. As a result, our data showed the existence of notable sex differences in gene expression patterns not obviously at E11.5, but clearly at E14.5 when neurogenesis has become its peak. These data can be useful for exploring potential contribution of genes exhibiting sex differences to the divergence in brain development. Additionally, our data underscore the significance of studying the embryonic period to gain a deeper understanding of sex differences in brain development.
摘要：
性别偏见在神经发育障碍的患病率/病理学中是已知的。已知某些大脑区域的性别依赖性差异是通过暴露于性激素而在围产期出现的，而啮齿动物胚胎大脑中的基因表达模式在男性和女性之间似乎并不完全相同。为了研究小鼠胚胎期基因表达和皮质组织的潜在性别差异，我们使用大量RNA-seq数据,对胚胎日(E)11.5天(神经干细胞扩增高峰)和E14.5天(神经发生高峰)端脑的基因表达进行了综合分析.因此,我们的数据显示，在E11.5基因表达模式中存在明显的性别差异，但在神经发生达到高峰时，E14.5基因表达模式中存在明显的性别差异。这些数据可用于探索表现出性别差异的基因对大脑发育差异的潜在贡献。此外,我们的数据强调了研究胚胎期对于更深入了解大脑发育中的性别差异的重要性。
