在 SMARCB1 缺陷型癌症中靶向依赖 CBP / p300 的旁系对对抗 KREMEN2 去抑制。
Mesh : SMARCB1 Protein / genetics metabolism Humans Animals Cell Line, Tumor Mice Gene Expression Regulation, Neoplastic p300-CBP Transcription Factors / metabolism genetics E1A-Associated p300 Protein / metabolism genetics Enhancer of Zeste Homolog 2 Protein / metabolism genetics antagonists & inhibitors Chromatin Assembly and Disassembly / genetics Mice, Nude RNA, Small Interfering / genetics metabolism Xenograft Model Antitumor Assays Promoter Regions, Genetic / genetics Cell Proliferation / genetics drug effects Rhabdoid Tumor / genetics metabolism pathology
来 源:
DOI:10.1038/s41467-024-49063-w
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