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Abstract：
OBJECTIVE: Migrants from high HIV, hepatitis B virus (HBV) or hepatitis C virus (HCV) endemicity regions have a great burden of these infections and related diseases in the host countries. This study aimed to assess the predictive capacity of the Test Rapide d\'Orientation Diagnostique (TROD) Screen questionnaire for HIV, HBV and HCV infections among migrants arriving in France.
METHODS: An observational and multicentre study was conducted among migrants. A self-questionnaire on demographic characteristics, personal medical history and sexual behaviours was completed.
METHODS: The study was conducted in the centres of the French Office for Immigration and Integration (OFII).
METHODS: Convenience sampling was used to select and recruit adult migrants between January 2017 and March 2020.
METHODS: Participants were tested for HIV, HBV and HCV with rapid tests. For each infection, the test performance was assessed using receiver operating characteristics curves, using area under the curve (AUC) as a measure of accuracy.
RESULTS: Among 21 133 regular migrants seen in OFII centres, 15 343 were included in the study. The participants\' mean age was 35.6 years (SD±11.1). The prevalence (95% CI) of HBV, HCV and HIV was 2.0% (1.8% to 2.2%), 0.3% (0.2% to 0.4%) and 0.3% (0.2% to 0.4%), respectively. Based on the sensitivity-specificity curve analysis, the cut-off points (95% CI) chosen for the risk score were: 2.5 (2.5 to 7.5) for HBV infection in men; 6.5 (0.5 to 6.5) for HBV infection in women; 9.5 (9.5 to 12.5) for HCV infection; and 10.5 (10.0 to 18.5) for HIV infection. Test performance was highest for HIV (AUC=82.15% (95% CI 74.54% to 87.99%)), followed by that for HBV in men (AUC=79.22%, (95% CI 76.18% to 82.26%)), for HBV in women (AUC=78.83 (95% CI 74.54% to 82.10%)) and that for HCV (AUC=75.95% (95% CI 68.58% to 83.32%)).
CONCLUSIONS: The TROD screen questionnaire showed good overall performance for predicting HIV, HBV and HCV infections among migrants in OFII centres. It could be used to optimise screening for these infections and to propose rapid screening tests to those who are at high risk.
BACKGROUND: NCT02959684.
METHODS: An observational and multicentre study was conducted among migrants. A self-questionnaire on demographic characteristics, personal medical history and sexual behaviours was completed.
METHODS: The study was conducted in the centres of the French Office for Immigration and Integration (OFII).
METHODS: Convenience sampling was used to select and recruit adult migrants between January 2017 and March 2020.
METHODS: Participants were tested for HIV, HBV and HCV with rapid tests. For each infection, the test performance was assessed using receiver operating characteristics curves, using area under the curve (AUC) as a measure of accuracy.
RESULTS: Among 21 133 regular migrants seen in OFII centres, 15 343 were included in the study. The participants\' mean age was 35.6 years (SD±11.1). The prevalence (95% CI) of HBV, HCV and HIV was 2.0% (1.8% to 2.2%), 0.3% (0.2% to 0.4%) and 0.3% (0.2% to 0.4%), respectively. Based on the sensitivity-specificity curve analysis, the cut-off points (95% CI) chosen for the risk score were: 2.5 (2.5 to 7.5) for HBV infection in men; 6.5 (0.5 to 6.5) for HBV infection in women; 9.5 (9.5 to 12.5) for HCV infection; and 10.5 (10.0 to 18.5) for HIV infection. Test performance was highest for HIV (AUC=82.15% (95% CI 74.54% to 87.99%)), followed by that for HBV in men (AUC=79.22%, (95% CI 76.18% to 82.26%)), for HBV in women (AUC=78.83 (95% CI 74.54% to 82.10%)) and that for HCV (AUC=75.95% (95% CI 68.58% to 83.32%)).
CONCLUSIONS: The TROD screen questionnaire showed good overall performance for predicting HIV, HBV and HCV infections among migrants in OFII centres. It could be used to optimise screening for these infections and to propose rapid screening tests to those who are at high risk.
BACKGROUND: NCT02959684.
摘要：
目标：艾滋病毒高发移民，乙型肝炎病毒（HBV）或丙型肝炎病毒（HCV）流行地区对这些感染和相关疾病的负担很大。本研究旨在评估测试快速诊断（TROD）筛查问卷对HIV的预测能力，到达法国的移民中的HBV和HCV感染。
方法：在移民中进行了一项观察性和多中心研究。关于人口特征的自我问卷，完成个人病史和性行为.
方法：这项研究是在法国移民与融合办公室（OFII）的中心进行的。
方法：在2017年1月至2020年3月期间，使用便利抽样来选择和招募成年移民。
方法：参与者接受了HIV检测，HBV和HCV快速检测。每次感染,使用接收器工作特性曲线评估测试性能，使用曲线下面积(AUC)作为准确度的量度。
结果：在OFII中心看到的21133名常规移民中，该研究包括15343。参与者的平均年龄为35.6岁（SD±11.1）。HBV的患病率（95%CI），HCV和HIV为2.0％（1.8％至2.2％），0.3%(0.2%至0.4%)和0.3%(0.2%至0.4%),分别。基于敏感性-特异性曲线分析,为风险评分选择的临界点(95%CI)为:男性HBV感染2.5(2.5~7.5);女性HBV感染6.5(0.5~6.5);HCV感染9.5(9.5~12.5);HIV感染10.5(10.0~18.5).HIV的测试性能最高（AUC=82.15%（95%CI74.54%至87.99%）），其次是男性HBV（AUC=79.22％，（95%CI76.18%至82.26%），女性HBV（AUC=78.83（95％CI74.54％至82.10％））和HCV（AUC=75.95％（95％CI68.58％至83.32％））。
结论：TROD筛查问卷显示出预测HIV的良好总体表现，OFII中心移民中的HBV和HCV感染。它可用于优化这些感染的筛查，并为高危人群提供快速筛查测试。
背景：NCT02959684。
方法：在移民中进行了一项观察性和多中心研究。关于人口特征的自我问卷，完成个人病史和性行为.
方法：这项研究是在法国移民与融合办公室（OFII）的中心进行的。
方法：在2017年1月至2020年3月期间，使用便利抽样来选择和招募成年移民。
方法：参与者接受了HIV检测，HBV和HCV快速检测。每次感染,使用接收器工作特性曲线评估测试性能，使用曲线下面积(AUC)作为准确度的量度。
结果：在OFII中心看到的21133名常规移民中，该研究包括15343。参与者的平均年龄为35.6岁（SD±11.1）。HBV的患病率（95%CI），HCV和HIV为2.0％（1.8％至2.2％），0.3%(0.2%至0.4%)和0.3%(0.2%至0.4%),分别。基于敏感性-特异性曲线分析,为风险评分选择的临界点(95%CI)为:男性HBV感染2.5(2.5~7.5);女性HBV感染6.5(0.5~6.5);HCV感染9.5(9.5~12.5);HIV感染10.5(10.0~18.5).HIV的测试性能最高（AUC=82.15%（95%CI74.54%至87.99%）），其次是男性HBV（AUC=79.22％，（95%CI76.18%至82.26%），女性HBV（AUC=78.83（95％CI74.54％至82.10％））和HCV（AUC=75.95％（95％CI68.58％至83.32％））。
结论：TROD筛查问卷显示出预测HIV的良好总体表现，OFII中心移民中的HBV和HCV感染。它可用于优化这些感染的筛查，并为高危人群提供快速筛查测试。
背景：NCT02959684。
