Abstract：
The influence of iron on collagen synthesis and vitamin D metabolism has implications for bone health. This cross-sectional observational study investigated associations between markers of iron status and tibial structure, vitamin D metabolites, and circulating biochemical markers of bone metabolism in young healthy men. A total of 343 male British Army recruits participated (age 22 ± 3 y, height 1.77 ± 0.06 m, body mass 75.5 ± 10.1 kg). Circulating biochemical markers of iron status, vitamin D metabolites, and bone metabolism, and tibial structure and density by high-resolution peripheral quantitative computed tomography scans (HRpQCT) were measured in participants during week 1 of basic military training. Associations between markers of iron status and HRpQCT outcomes, bone metabolism, and vitamin D metabolites were tested, controlling for age, height, lean body mass, and childhood exercise volume. Higher ferritin was associated with higher total, trabecular, and cortical volumetric bone mineral density, trabecular volume, cortical area and thickness, stiffness, and failure load (all p ≤ 0.037). Higher soluble transferrin receptor (sTfR) was associated with lower trabecular number, and higher trabecular thickness and separation, cortical thickness, and cortical pore diameter (all p ≤ 0.033). Higher haemoglobin was associated with higher cortical thickness (p = 0.043). Higher ferritin was associated with lower βCTX, PINP, total 25(OH)D, and total 24,25(OH)2D, and higher 1,25(OH)2D:24,25(OH)2D ratio (all p ≤ 0.029). Higher sTfR was associated with higher PINP, total 25(OH)D, and total 24,25(OH)2D (all p ≤ 0.025). The greater density, size, and strength of the tibia, and lower circulating concentrations of markers of bone resorption and formation with better iron stores (higher ferritin) are likely as a result of the direct role of iron in collagen synthesis.
摘要：
铁对胶原蛋白合成和维生素D代谢的影响对骨骼健康具有重要意义。这项横断面观察研究调查了铁状态标志物与胫骨结构之间的关联。维生素D代谢物，和年轻健康男性骨代谢的循环生化标志物。共有343名英军男性新兵参加（年龄22±3岁，高度1.77±0.06m，体重75.5±10.1kg)。循环生化标志物的铁状态，维生素D代谢物，和骨骼代谢，在基础军事训练的第1周，通过高分辨率外周定量计算机断层扫描（HRpQCT）测量了参与者的胫骨结构和密度。铁状态标志物与HRpQCT结果之间的关联，骨代谢，并对维生素D代谢产物进行了测试，控制年龄，高度,瘦体重,和童年运动量。较高的铁蛋白与较高的总含量有关，小梁,和皮质骨矿物质密度，小梁体积,皮质面积和厚度，刚度,和破坏载荷(所有p≤0.037)。较高的可溶性转铁蛋白受体（sTfR）与较低的小梁数量有关，和更高的小梁厚度和分离，皮质厚度,和皮质孔径（均p≤0.033）。较高的血红蛋白与较高的皮质厚度相关(p=0.043)。较高的铁蛋白与较低的βCTX相关，PINP,总计25（OH）D，总共24,25(OH)2D，和更高的1,25（OH）2D：24,25（OH）2D比率（所有p≤0.029）。较高的sTfR与较高的PINP相关，总计25（OH）D，和总计24,25（OH）2D（所有p≤0.025）。密度越大,尺寸,和胫骨的力量，和较低的循环浓度的骨吸收和形成标记与更好的铁储存（较高的铁蛋白）可能是铁在胶原蛋白合成中的直接作用的结果。
