Abstract：
A growing body of evidence has shown the effects of poor preconception health on adverse pregnancy outcomes and, subsequently, maternal and child morbidity and mortality. However, the cost of poor preconception health remains relatively unexplored. Using the case of Nigeria, this study provides the first estimate of the disease and economic burden of poor preconception health at a country level. Using data from international databases and the scientific literature, the study used a cost-of-illness approach to quantify the foregone productivity and direct healthcare costs resulting from six preconception risk factors (adolescent pregnancy, short birth interval, overweight and obesity, intimate partner violence, female genital mutilation, folate deficiency). The results indicate that 6.7% of maternal deaths, 10.9% of perinatal deaths, and 10.5% of late neonatal deaths were attributable to the selected preconception risk factors in 2020. The economic burden of poor preconception health in Nigeria was estimated at US$ 3.3 billion in 2020, of which over 90% was generated by premature mortality. If prevalence rates remain constant, total economic losses could amount to US$ 46.2 billion by 2035. This analysis paves the way for further studies investigating the economic costs and benefits of preconception interventions and policies in low and middle-income countries.
摘要：
越来越多的证据表明，孕前健康状况不佳对不良妊娠结局的影响，随后,母婴发病率和死亡率。然而,孕前健康状况不佳的成本仍未被探索。以尼日利亚为例，这项研究提供了在国家层面上对孕前健康状况不佳的疾病和经济负担的首次估计。使用来自国际数据库和科学文献的数据，该研究使用疾病成本方法来量化由六个孕前风险因素（青春期怀孕，出生间隔短,超重和肥胖，亲密伴侣暴力，切割女性生殖器官,叶酸缺乏)。结果表明，6.7%的孕产妇死亡，10.9%的围产期死亡,在2020年，10.5%的晚期新生儿死亡归因于选定的孕前危险因素。尼日利亚孕前健康状况不佳的经济负担在2020年估计为33亿美元，其中90%以上是过早死亡造成的。如果患病率保持不变，到2035年，总经济损失可能达到462亿美元。该分析为进一步研究中低收入国家的概念前干预措施和政策的经济成本和收益铺平了道路。
