PDF(Pubmed)
Abstract：
Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses a significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly in histone modifications, DNA methylation, and microRNAs, play a pivotal role in unraveling the complex molecular underpinnings of blood pressure regulation. This review emphasizes the crucial interplay between epigenetic attributes and hypertension, shedding light on the prominence of DNA methylation, both globally and at the gene-specific level, in essential hypertension. Additionally, histone modifications, including acetylation and methylation, emerge as essential epigenetic markers linked to hypertension. Furthermore, microRNAs exert regulatory influence on blood pressure homeostasis, targeting key genes within the aldosterone and renin-angiotensin pathways. Understanding the intricate crosstalk between genetics and epigenetics in hypertension is particularly pertinent in the context of its interaction with T2DM, where hypertension serves as a notable risk factor for the development of CAD. These findings not only contribute to the comprehensive elucidation of essential hypertension but also offer promising avenues for innovative strategies in the prevention and treatment of cardiovascular complications, especially in the context of T2DM.
摘要：
高血压,受遗传影响的多方面心血管疾病，表观遗传,和环境因素，在2型糖尿病（T2DM）患者中，冠状动脉疾病（CAD）的发展存在重大风险。表观遗传改变,特别是在组蛋白修饰中，DNA甲基化，和microRNAs，在解开血压调节的复杂分子基础中起着关键作用。这篇综述强调了表观遗传属性与高血压之间的关键相互作用。揭示DNA甲基化的突出，在全球和基因特异性水平上，原发性高血压。此外,组蛋白修饰，包括乙酰化和甲基化，成为与高血压相关的重要表观遗传标记。此外，microRNAs对血压稳态有调节作用,靶向醛固酮和肾素-血管紧张素途径内的关键基因。了解高血压中遗传学和表观遗传学之间复杂的串扰在其与T2DM的相互作用中是特别相关的。其中高血压是CAD发展的显着危险因素。这些发现不仅有助于全面阐明原发性高血压，而且为预防和治疗心血管并发症的创新策略提供了有希望的途径。尤其是在T2DM的背景下。
