PDF(Pubmed)
Abstract：
Legionella, one of the main pathogens that causes community-acquired pneumonia, can lead to Legionella pneumonia, a condition characterized predominantly by severe pneumonia. This disease, caused by the bacterium Legionella pneumophila, can quickly progress to critical pneumonia and is often associated with damage to multiple organs. As a result, it requires close attention in terms of clinical diagnosis and treatment. Omadacycline, a new type of tetracycline derivative belonging to the aminomethylcycline class of antibiotics, is a semi-synthetic compound derived from minocycline. Its key structural feature, the aminomethyl modification, allows omadacycline to overcome bacterial resistance and broadens its range of effectiveness against bacteria. Clinical studies have demonstrated that omadacycline is not metabolized in the body, and patients with hepatic and renal dysfunction do not need to adjust their dosage. This paper reports a case of successful treatment of Legionella pneumonia with omadacycline in a patient who initially did not respond to empirical treatment with moxifloxacin. The patient also experienced electrolyte disturbance, as well as dysfunction in the liver and kidneys, delirium, and other related psychiatric symptoms.
摘要：
军团菌,导致社区获得性肺炎的主要病原体之一，会导致军团菌肺炎,以严重肺炎为主要特征的病症。这种疾病,由嗜肺军团菌引起，可以迅速发展为危重肺炎，并且通常与多个器官的损害有关。因此,在临床诊断和治疗方面需要密切关注。Omadacycline,一种属于氨基甲基环素类抗生素的新型四环素衍生物，是衍生自米诺环素的半合成化合物。其主要结构特点，氨甲基改性，允许omadacycline克服细菌耐药性并扩大其对细菌的有效性范围。临床研究表明，奥马环素在体内不代谢，肝肾功能不全患者不需要调整剂量。本文报道了一例最初对莫西沙星经验性治疗无反应的患者，使用奥马环素成功治疗了军团菌肺炎。患者还经历了电解质紊乱，以及肝脏和肾脏的功能障碍，谵妄,和其他相关的精神症状。
