PDF(Pubmed)
Abstract：
UNASSIGNED: Depressive syndrome (DS) is a common complication during pregnancy and the postpartum period, and is triggered by multiple organic/genetic and environmental factors. Clinical and biochemical follow-up is essential for the early diagnosis and prognosis of DS. The protozoan Toxoplasma gondii causes infectious damage to the fetus during parasite primary-infection. However, in long-term infections, pregnant women develop immune protection to protect the fetus, although they remain susceptible to pathological or inflammatory effects induced by T. gondii. This study aimed to investigate plasma inflammatory biomarkers in pregnant women seropositive and seronegative for T. gondii, with diagnoses of minor and moderate/severe DS.
UNASSIGNED: Pregnant women (n=45; age=18-39 years) were recruited during prenatal care at health centers in Ouro Preto, Minas Gerais, Brazil. Participants were asked to complete a socio-demographic questionnaire to be submitted to well-standardized DS scale calculators (Beck Depression Inventory Questionnaire, Edinburgh Postnatal Depression Scale, and Major Depressive Episode Module). Additionally, 4 mL of blood was collected for plasma neuroserpin, CCL2, IL-17A, and IL-33 analysis.
UNASSIGNED: Pregnant volunteers with chronic T. gondii contact were all IgG+ (44%; n=21) and exhibited increased plasma IL-33, IL-17A, and neuroserpin levels, but not CCL2, compared to uninfected pregnant women. Using Beck\'s depression inventory, we observed an increase in plasma IL-17A and IL-33 in women with T. gondii infeCction diagnosed with mild DS, whereas neuroserpin was associated with minor and moderate/severe DS.
UNASSIGNED: Our data suggest a close relationship between DS in pregnant women with chronic T. gondii infection and neurological conditions, which may be partially mediated by plasma neuroserpin, IL-33, and IL-17A levels.
UNASSIGNED: Pregnant women (n=45; age=18-39 years) were recruited during prenatal care at health centers in Ouro Preto, Minas Gerais, Brazil. Participants were asked to complete a socio-demographic questionnaire to be submitted to well-standardized DS scale calculators (Beck Depression Inventory Questionnaire, Edinburgh Postnatal Depression Scale, and Major Depressive Episode Module). Additionally, 4 mL of blood was collected for plasma neuroserpin, CCL2, IL-17A, and IL-33 analysis.
UNASSIGNED: Pregnant volunteers with chronic T. gondii contact were all IgG+ (44%; n=21) and exhibited increased plasma IL-33, IL-17A, and neuroserpin levels, but not CCL2, compared to uninfected pregnant women. Using Beck\'s depression inventory, we observed an increase in plasma IL-17A and IL-33 in women with T. gondii infeCction diagnosed with mild DS, whereas neuroserpin was associated with minor and moderate/severe DS.
UNASSIGNED: Our data suggest a close relationship between DS in pregnant women with chronic T. gondii infection and neurological conditions, which may be partially mediated by plasma neuroserpin, IL-33, and IL-17A levels.
摘要：
■抑郁综合征（DS）是妊娠期和产后常见的并发症，由多种有机/遗传和环境因素触发。临床和生化随访对DS的早期诊断和预后至关重要。原生动物弓形虫在寄生虫初次感染时会对胎儿造成感染性损害。然而,在长期感染中，孕妇发展免疫保护以保护胎儿，尽管它们仍然容易受到弓形虫诱导的病理或炎症作用。本研究旨在探讨孕妇弓形虫血清阳性和血清阴性的血浆炎症生物标志物。诊断为轻度和中度/重度DS。
■孕妇（n=45；年龄=18-39岁）在OuroPreto的保健中心进行产前护理期间被招募，米纳斯吉拉斯州,巴西。参与者被要求完成一份社会人口统计问卷，提交给标准化的DS量表计算器(贝克抑郁量表问卷，爱丁堡产后抑郁量表，和重度抑郁发作模块)。此外,收集4mL血液用于血浆神经素素，CCL2,IL-17A,和IL-33分析。
■患有慢性弓形虫接触的妊娠志愿者均为IgG（44％；n=21），血浆IL-33，IL-17A增加，和神经血清素水平，但不是CCL2，与未感染的孕妇相比。用贝克的抑郁症清单，在诊断为轻度DS的弓形虫感染女性中，我们观察到血浆IL-17A和IL-33的增加，而neuroserpin与轻度和中度/重度DS相关。
■我们的数据表明，患有慢性弓形虫感染的孕妇的DS与神经系统疾病密切相关，可能部分由血浆神经酶素介导，IL-33和IL-17A水平。
■孕妇（n=45；年龄=18-39岁）在OuroPreto的保健中心进行产前护理期间被招募，米纳斯吉拉斯州,巴西。参与者被要求完成一份社会人口统计问卷，提交给标准化的DS量表计算器(贝克抑郁量表问卷，爱丁堡产后抑郁量表，和重度抑郁发作模块)。此外,收集4mL血液用于血浆神经素素，CCL2,IL-17A,和IL-33分析。
■患有慢性弓形虫接触的妊娠志愿者均为IgG（44％；n=21），血浆IL-33，IL-17A增加，和神经血清素水平，但不是CCL2，与未感染的孕妇相比。用贝克的抑郁症清单，在诊断为轻度DS的弓形虫感染女性中，我们观察到血浆IL-17A和IL-33的增加，而neuroserpin与轻度和中度/重度DS相关。
■我们的数据表明，患有慢性弓形虫感染的孕妇的DS与神经系统疾病密切相关，可能部分由血浆神经酶素介导，IL-33和IL-17A水平。
