PDF(Pubmed)
Abstract：
UNASSIGNED: The number of patients with skin and soft tissue infections (SSTIs) in the United States appeared to be increasing well into the 21st century. However, no recent data have confirmed this trend.
UNASSIGNED: This retrospective, observational cohort study used claims data over 11 years (2010-2020) from Optum\'s de-identified Clinformatics Data Mart Database. SSTI episodes, complications, and comorbidities were identified using International Classification of Diseases codes. Annual SSTI incidence rates, proportions of recurrent SSTI, SSTI-associated deaths, and total costs were estimated.
UNASSIGNED: During the study period, 5.4 million patients experienced 9.1 million SSTI episodes, with an incidence of 77.5 (95% confidence interval, 77.4-77.5) per 1000 person-years of observation (PYO). Annual incidence did not change significantly over time. Overall incidence (per 1000 PYO) of SSTI episodes in patients without comorbidities was 32.1 (highest incidence was for previous SSTI [113.5]) versus much higher rates if comorbidities were present. Incidence rates (per 1000 PYO) of chronic ulcers increased over time from 11.3 to 18.2 (P < .0001) and complicated disease from 3.5 to 6.3 (P < .0001). Deaths occurring within 30 days post-SSTI hospitalization rose from 2.6% to 4.6% in 2020. Recurrences occurred in 26.3% of index cases. The mean cost of an SSTI episode was US$3334 (median US$190) and was highest for surgical site infections and chronic ulcers.
UNASSIGNED: The epidemiology of SSTI in the United States is changing and the disease burden is increasing despite stabilization in overall incidence. These data can inform identification of priority populations who could benefit from targeted interventions.
UNASSIGNED: This retrospective, observational cohort study used claims data over 11 years (2010-2020) from Optum\'s de-identified Clinformatics Data Mart Database. SSTI episodes, complications, and comorbidities were identified using International Classification of Diseases codes. Annual SSTI incidence rates, proportions of recurrent SSTI, SSTI-associated deaths, and total costs were estimated.
UNASSIGNED: During the study period, 5.4 million patients experienced 9.1 million SSTI episodes, with an incidence of 77.5 (95% confidence interval, 77.4-77.5) per 1000 person-years of observation (PYO). Annual incidence did not change significantly over time. Overall incidence (per 1000 PYO) of SSTI episodes in patients without comorbidities was 32.1 (highest incidence was for previous SSTI [113.5]) versus much higher rates if comorbidities were present. Incidence rates (per 1000 PYO) of chronic ulcers increased over time from 11.3 to 18.2 (P < .0001) and complicated disease from 3.5 to 6.3 (P < .0001). Deaths occurring within 30 days post-SSTI hospitalization rose from 2.6% to 4.6% in 2020. Recurrences occurred in 26.3% of index cases. The mean cost of an SSTI episode was US$3334 (median US$190) and was highest for surgical site infections and chronic ulcers.
UNASSIGNED: The epidemiology of SSTI in the United States is changing and the disease burden is increasing despite stabilization in overall incidence. These data can inform identification of priority populations who could benefit from targeted interventions.
摘要：
■进入21世纪，美国皮肤和软组织感染（STTI）的患者数量似乎正在增加。然而,最近没有数据证实这一趋势。
■这次回顾展，观察性队列研究使用了Optum去识别的诊所数据集市数据库中超过11年(2010-2020年)的索赔数据.SSTI情节，并发症,并使用国际疾病分类代码确定合并症。SSTI年发病率，复发性SSTI的比例，SSTI相关死亡,并估算了总成本。
■在研究期间，540万患者经历了910万SSTI发作，发生率为77.5(95%置信区间，77.4-77.5）每1000人年观察（PYO）。年发病率随时间变化不明显。在没有合并症的患者中，SSTI发作的总发生率（每1000个PYO）为32.1（以前的SSTI发生率最高[113.5]），如果存在合并症，则发生率更高。慢性溃疡的发病率（每1000个PYO）随着时间的推移从11.3增加到18.2（P<.0001），复杂疾病从3.5增加到6.3（P<.0001）。SSTI住院后30天内的死亡人数从2.6%上升到2020年的4.6%。复发发生在26.3％的索引病例中。SSTI发作的平均费用为3334美元（中位数为190美元），手术部位感染和慢性溃疡的费用最高。
■尽管总体发病率稳定，但美国SSTI的流行病学正在发生变化，疾病负担正在增加。这些数据可以为确定可以从有针对性的干预措施中受益的优先人群提供信息。
■这次回顾展，观察性队列研究使用了Optum去识别的诊所数据集市数据库中超过11年(2010-2020年)的索赔数据.SSTI情节，并发症,并使用国际疾病分类代码确定合并症。SSTI年发病率，复发性SSTI的比例，SSTI相关死亡,并估算了总成本。
■在研究期间，540万患者经历了910万SSTI发作，发生率为77.5(95%置信区间，77.4-77.5）每1000人年观察（PYO）。年发病率随时间变化不明显。在没有合并症的患者中，SSTI发作的总发生率（每1000个PYO）为32.1（以前的SSTI发生率最高[113.5]），如果存在合并症，则发生率更高。慢性溃疡的发病率（每1000个PYO）随着时间的推移从11.3增加到18.2（P<.0001），复杂疾病从3.5增加到6.3（P<.0001）。SSTI住院后30天内的死亡人数从2.6%上升到2020年的4.6%。复发发生在26.3％的索引病例中。SSTI发作的平均费用为3334美元（中位数为190美元），手术部位感染和慢性溃疡的费用最高。
■尽管总体发病率稳定，但美国SSTI的流行病学正在发生变化，疾病负担正在增加。这些数据可以为确定可以从有针对性的干预措施中受益的优先人群提供信息。
