PDF(Pubmed)
Abstract：
BACKGROUND: Cervical cancer is one of the leading causes of death in women worldwide. The majority of the cases are found in developing countries. The increasing risk of cervical cancer prevalence and growing danger of death from cervical cancer and the high occurrence of human papillomavirus (HPV) infection in women who are HIV positive give us the ground to study the prevalence and associated risk factors.
OBJECTIVE: The study aims to assess the prevalence of cervical cancer screening and associated risk factors among HIV-positive women attending the Adult ART clinic at the University of Gondar Hospital.
METHODS: An institution-based cross-sectional study was conducted from March to August 2021, on adult HIV-positive women attending the Adult ART clinic at Gondar University Referral Hospital by phone calling patients per week for six months to complete a total of 2744 HIV-positive patients who were not screened for cervical cancer before. The data were collected using an interviewer-administered questionnaire. Bivariate and multivariable logistic regression analyses were used to determine the presence and the degree of association between dependent and independent variables. In the multivariable logistic analysis, a P-value of < 0.05 and odds ratio with a 95% confidence interval were considered to determine independent predictors for the prevalence of premalignant or malignant cervical lesions among HIV-positive patients.
RESULTS: This study assessed 915 HIV Positive women who were screened for cervical cancer via visual inspection with acetic acid (VIA) as the primary screening tool and found that 24.48% had positive VIA results. Those with VIA-positive cases pathology examination showed 72.4% had abnormal pathology reports (CIN 1/2/3-51.25%, 17.23% cancer & 3.9% CIS), strengthening the finding in many studies that suggest HIV-positive women have a high rate of premalignant lesions.
OBJECTIVE: The study aims to assess the prevalence of cervical cancer screening and associated risk factors among HIV-positive women attending the Adult ART clinic at the University of Gondar Hospital.
METHODS: An institution-based cross-sectional study was conducted from March to August 2021, on adult HIV-positive women attending the Adult ART clinic at Gondar University Referral Hospital by phone calling patients per week for six months to complete a total of 2744 HIV-positive patients who were not screened for cervical cancer before. The data were collected using an interviewer-administered questionnaire. Bivariate and multivariable logistic regression analyses were used to determine the presence and the degree of association between dependent and independent variables. In the multivariable logistic analysis, a P-value of < 0.05 and odds ratio with a 95% confidence interval were considered to determine independent predictors for the prevalence of premalignant or malignant cervical lesions among HIV-positive patients.
RESULTS: This study assessed 915 HIV Positive women who were screened for cervical cancer via visual inspection with acetic acid (VIA) as the primary screening tool and found that 24.48% had positive VIA results. Those with VIA-positive cases pathology examination showed 72.4% had abnormal pathology reports (CIN 1/2/3-51.25%, 17.23% cancer & 3.9% CIS), strengthening the finding in many studies that suggest HIV-positive women have a high rate of premalignant lesions.
摘要：
背景：宫颈癌是全球女性死亡的主要原因之一。大多数病例发生在发展中国家。宫颈癌患病率的增加和宫颈癌死亡的增加的危险以及HIV阳性女性中人乳头瘤病毒（HPV）感染的高发生率为我们研究患病率和相关危险因素奠定了基础。
目的：该研究旨在评估在冈达尔大学医院成人ART诊所就诊的HIV阳性妇女中宫颈癌筛查的患病率和相关危险因素。
方法：于2021年3月至8月进行了一项基于机构的横断面研究，对在冈达尔大学转诊医院成人ART诊所就诊的成年HIV阳性妇女进行了为期六个月的电话呼叫，以完成总共2744名以前未接受宫颈癌筛查的HIV阳性患者。使用面试官管理的问卷收集数据。使用双变量和多变量逻辑回归分析来确定因变量和自变量之间的存在和关联程度。在多变量逻辑分析中，<0.05的P值和95%置信区间的比值比被认为是确定HIV阳性患者中宫颈癌前病变或恶性病变患病率的独立预测因子.
结果：这项研究评估了915名HIV阳性妇女，这些妇女通过目视检查以乙酸（VIA）为主要筛查工具进行了宫颈癌筛查，发现24.48％的患者的VIA结果为阳性。VIA阳性病例病理检查显示72.4%有异常病理报告(CIN1/2/3-51.25%,17.23%癌症和3.9%CIS），加强了许多研究中的发现，这些研究表明HIV阳性妇女的癌前病变发生率很高。
目的：该研究旨在评估在冈达尔大学医院成人ART诊所就诊的HIV阳性妇女中宫颈癌筛查的患病率和相关危险因素。
方法：于2021年3月至8月进行了一项基于机构的横断面研究，对在冈达尔大学转诊医院成人ART诊所就诊的成年HIV阳性妇女进行了为期六个月的电话呼叫，以完成总共2744名以前未接受宫颈癌筛查的HIV阳性患者。使用面试官管理的问卷收集数据。使用双变量和多变量逻辑回归分析来确定因变量和自变量之间的存在和关联程度。在多变量逻辑分析中，<0.05的P值和95%置信区间的比值比被认为是确定HIV阳性患者中宫颈癌前病变或恶性病变患病率的独立预测因子.
结果：这项研究评估了915名HIV阳性妇女，这些妇女通过目视检查以乙酸（VIA）为主要筛查工具进行了宫颈癌筛查，发现24.48％的患者的VIA结果为阳性。VIA阳性病例病理检查显示72.4%有异常病理报告(CIN1/2/3-51.25%,17.23%癌症和3.9%CIS），加强了许多研究中的发现，这些研究表明HIV阳性妇女的癌前病变发生率很高。
