PDF(Pubmed)
Abstract：
The present cross-sectional study aimed to explore the relationship between systemic inflammatory indices (SIIs) and anthropometric measures, metabolic, and liver function biomarkers in patients with non-alcoholic fatty liver disease (NAFLD). This study was carried out on 238 NAFLD patients with overweight or obesity, aged 18-55 years. Anthropometric measurements were done and body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were estimated. Metabolic factors including serum glucose, lipid profile, liver function biomarkers, and complete blood cell count were assessed after a 24-h fasting state. SIIs including the ratios of neutrophil to lymphocyte (NLR), monocytes to lymphocyte (MLR), platelet to lymphocyte (PLR), and monocytes to high-density lipoprotein cholesterol (MHR) were calculated. Results indicate that apart from PLR, all of the SIIs significantly changed by increasing steatosis severity (all p < 0.05). Moreover, changes in NLR showed a significant association with anthropometric indices including waist circumference (p = 0.032), BMI (p = 0.047), and WHtR (p = 0.002), as well as levels of fasting blood sugar (p = 0.045), triglycerides, (p = 0.025) and low-density lipoprotein cholesterol (p = 0.006). The findings also indicate the relations between lipid profile and all studied SIIs, notably MHR and MLR. All of the SIIs exhibited associations with some liver function indices as well. MHR was positively correlated with the metabolic risk factors of NAFLD while, oppositely, PLR was considered as a preventive marker of NAFLD.
摘要：
本横断面研究旨在探讨全身炎症指数(SII)与人体测量之间的关系。新陈代谢，非酒精性脂肪性肝病（NAFLD）患者的肝功能生物标志物。这项研究是对238名超重或肥胖的NAFLD患者进行的，18-55岁。进行人体测量和体重指数（BMI），腰臀比（WHR），和腰高比（WHtR）进行了估计。代谢因素包括血清葡萄糖，血脂谱,肝功能生物标志物，和全血细胞计数在24小时禁食状态后进行评估。SII包括中性粒细胞与淋巴细胞（NLR）的比率，单核细胞至淋巴细胞（MLR），血小板淋巴细胞（PLR），计算单核细胞对高密度脂蛋白胆固醇（MHR）的影响。结果表明，除了PLR，所有的SII随着脂肪变性严重程度的增加而显著改变(所有p<0.05)。此外，NLR的变化与包括腰围在内的人体测量指标显着相关（p=0.032），BMI（p=0.047），和WHtR(p=0.002)，以及空腹血糖水平（p=0.045），甘油三酯，（p=0.025）和低密度脂蛋白胆固醇（p=0.006）。这些发现还表明了血脂谱与所有研究的SII之间的关系，特别是MHR和MLR。所有SII也表现出与某些肝功能指标的关联。MHR与NAFLD的代谢危险因素呈正相关,相反，PLR被认为是NAFLD的预防性标志物。
