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Abstract：
Leuconostoc species are regarded as important causes for many infections in immunocompromised patients. In this study, we assessed the characteristics of Leuconostoc spp. causing bacteremia in patients at our center. This observational analysis was conducted in the microbiology laboratory of a tertiary care center in northern India from July 2021 to July 2023. Patients in whom blood culture bottles were positive for Leuconostoc lactis were included in the study. Culture isolates were identified by MALDI-ToF MS as L. lactis and tested for antibiotic sensitivity results by Kirby-Bauer disk diffusion method. Demographic and clinical details were collected and analyzed. During the study period, 6,742 blood culture bottles flagged positive. Among these, L. lactis was isolated from 14 (0.21%) patients. The median patient age was 34 years. The male-to-female ratio was 2.5:1. All the patients with L. lactis bacteremia had an underlying condition leading to immunosuppression (e.g., carcinoma and chronic kidney disease). All the patients with L. lactis bacteremia had an intravascular device present at the time of bacteremia. All isolates in the study were sensitive to doxycycline, high level gentamicin, minocycline, ampicillin-sulbactam, and linezolid. Mortality was attributed to bacteremia by L. lactis in five patients. Appropriate and timely identification of the Leuconostoc species is important for the clinician to tailor regimens for the patients.
摘要：
明串珠菌种被认为是免疫功能低下患者中许多感染的重要原因。在这项研究中,我们评估了明串珠菌属的特征。导致我们中心患者菌血症.这项观察性分析于2021年7月至2023年7月在印度北部三级护理中心的微生物学实验室进行。血液培养瓶对乳明串珠菌呈阳性的患者被纳入研究。通过MALDI-ToFMS将培养物分离株鉴定为乳酸乳球菌，并通过Kirby-Bauer圆盘扩散法测试抗生素敏感性结果。收集和分析人口统计学和临床细节。在学习期间,6,742个血液培养瓶标记为阳性。其中,从14例（0.21％）患者中分离出乳酸乳球菌。患者年龄中位数为34岁。男女比例为2.5:1。所有患有乳酸乳球菌菌血症的患者都有导致免疫抑制的潜在病症(例如，癌症和慢性肾脏疾病)。所有患有乳酸乳球菌菌血症的患者在菌血症时都存在血管内装置。研究中的所有分离株对强力霉素敏感,高水平的庆大霉素,米诺环素,氨苄西林-舒巴坦,和利奈唑胺.5例患者的死亡率归因于乳酸乳球菌菌血症。适当和及时地识别明串珠菌种对于临床医生为患者定制治疗方案很重要。
