METHODS: Data from the Veterans Health Administration (VHA) Corporate Data Warehouse administrative data were used to identify 56,556 VWE (5.7 % HL-VWE) using a one-year cross-sectional analysis of ICD codes. Elixhauser Comorbidity Index scores and psychiatric diagnoses were calculated based on ICD-9/ICD-10-CM diagnoses using a lookback period. Comparisons were made between HL-VWE and non-HL-VWE using chi-squared and student t-tests. Regression analyses were then performed to examine group differences while accounting for age.
RESULTS: HL-VWE had higher probability of being diagnosed with several psychiatric conditions when accounting for age, including depression (OR 1.21, 95 % CI 1.13-1.31) and schizophrenia (OR 1.56, 95 % CI 1.31-1.84). There were no significant differences in medical comorbidities between the HL-VWE and non-HL-VWE groups.
CONCLUSIONS: We present results from the largest known study of HL people with epilepsy examining their psychiatric and medical comorbidities and one of the first to specifically study HL-VWE. Compared to non-HL-VWE, the Hispanic/Latino group had comparable medical comorbidity, but higher rates of multiple psychiatric conditions. Results indicate a need for increased screening and interventions in this population to reduce psychiatric disease burden.
方法:使用来自退伍军人健康管理局(VHA)企业数据仓库管理数据的数据,通过对ICD代码进行为期一年的横截面分析,识别出56,556个VWE(5.7%HL-VWE)。Elixhauser合并症指数评分和精神病诊断是根据ICD-9/ICD-10-CM诊断使用回顾期计算的。使用卡方和学生t检验在HL-VWE和非HL-VWE之间进行比较。然后进行回归分析以检查群体差异,同时考虑年龄。
结果:考虑到年龄,HL-VWE被诊断患有多种精神疾病的可能性更高,包括抑郁症(OR1.21,95%CI1.13-1.31)和精神分裂症(OR1.56,95%CI1.31-1.84)。HL-VWE组和非HL-VWE组之间的医学合并症没有显着差异。
结论:我们介绍了已知最大的HL癫痫患者研究结果,该研究检查了他们的精神和医学合并症,也是第一个专门研究HL-VWE的研究结果。与非HL-VWE相比,西班牙裔/拉丁裔组有类似的医学合并症,但多种精神疾病的发病率更高。结果表明,需要在该人群中增加筛查和干预措施,以减少精神疾病负担。