Abstract：
OBJECTIVE: This study aimed to evaluate the potential role of 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) in providing a targeted approach for diagnosing the etiology of Pyrexia of Unknown Origin (PUO).
METHODS: A total of 573 PUO patients were included in this ambispective study, with a mean age of 39.40 ± 4.6 years. Patients underwent FDG PET/CT scans using dedicated hybrid scanners. PET/CT data were interpreted by experienced nuclear medicine physicians. The study analyzed the guidance provided by FDG PET/CT for appropriate biopsy sites and assessed concordance between PET/CT findings and histopathological examination.
RESULTS: Out of the 573 patients, a final diagnosis was reached for 219 patients, including malignancy, infectious causes, noninfectious inflammatory causes (NIID), and precancerous conditions. FDG PET/CT played a crucial role in guiding clinicians to appropriate biopsy sites, contributing to a higher diagnostic yield. Concordance between PET/CT findings and histopathological examination emphasized the noninvasive diagnostic potential of PET/CT in identifying underlying causes of PUO. Overall, FDG PET/CT contributed to guiding the appropriate site of biopsy or concordance of the first differential diagnosis with the final diagnosis in 50.05% of cases.
CONCLUSIONS: This study highlights the valuable role of FDG PET/CT in providing a targeted approach for diagnosing PUO, showcasing its potential in guiding clinicians towards appropriate biopsy sites and improving the diagnostic yield. The findings underscore the importance of integrating FDG PET/CT into the diagnostic pathway for PUO, ultimately enhancing patient management and outcomes. Further prospective studies are necessary to validate these results and refine the integration of FDG PET/CT in the diagnosis of PUO.
METHODS: A total of 573 PUO patients were included in this ambispective study, with a mean age of 39.40 ± 4.6 years. Patients underwent FDG PET/CT scans using dedicated hybrid scanners. PET/CT data were interpreted by experienced nuclear medicine physicians. The study analyzed the guidance provided by FDG PET/CT for appropriate biopsy sites and assessed concordance between PET/CT findings and histopathological examination.
RESULTS: Out of the 573 patients, a final diagnosis was reached for 219 patients, including malignancy, infectious causes, noninfectious inflammatory causes (NIID), and precancerous conditions. FDG PET/CT played a crucial role in guiding clinicians to appropriate biopsy sites, contributing to a higher diagnostic yield. Concordance between PET/CT findings and histopathological examination emphasized the noninvasive diagnostic potential of PET/CT in identifying underlying causes of PUO. Overall, FDG PET/CT contributed to guiding the appropriate site of biopsy or concordance of the first differential diagnosis with the final diagnosis in 50.05% of cases.
CONCLUSIONS: This study highlights the valuable role of FDG PET/CT in providing a targeted approach for diagnosing PUO, showcasing its potential in guiding clinicians towards appropriate biopsy sites and improving the diagnostic yield. The findings underscore the importance of integrating FDG PET/CT into the diagnostic pathway for PUO, ultimately enhancing patient management and outcomes. Further prospective studies are necessary to validate these results and refine the integration of FDG PET/CT in the diagnosis of PUO.
摘要：
目的：本研究旨在评估18F-氟代脱氧葡萄糖PET/计算机断层扫描（18F-FDGPET/CT）在诊断不明原因发热（PUO）病因中的潜在作用。
方法：共有573名PUO患者被纳入这项综合研究，平均年龄39.40±4.6岁。患者使用专用混合扫描仪进行FDGPET/CT扫描。PET/CT数据由经验丰富的核医学医师解释。该研究分析了FDGPET/CT对适当活检部位的指导，并评估了PET/CT发现与组织病理学检查之间的一致性。
结果：在573名患者中，219例患者最终确诊,包括恶性肿瘤,传染性原因,非感染性炎症原因（NIID），和癌前病变.FDGPET/CT在指导临床医生选择合适的活检部位中起着至关重要的作用。有助于更高的诊断产量。PET/CT发现与组织病理学检查之间的一致性强调了PET/CT在确定PUO的潜在原因方面的无创诊断潜力。总的来说,在50.05％的病例中，FDGPET/CT有助于指导活检的适当部位或首次鉴别诊断与最终诊断的一致性。
结论：这项研究强调了FDGPET/CT在提供诊断PUO的靶向方法方面的重要作用。展示了其在指导临床医生进行适当的活检部位和提高诊断率方面的潜力。这些发现强调了将FDGPET/CT整合到PUO诊断途径中的重要性，最终提高患者管理和结果。需要进一步的前瞻性研究来验证这些结果并完善FDGPET/CT在PUO诊断中的整合。
方法：共有573名PUO患者被纳入这项综合研究，平均年龄39.40±4.6岁。患者使用专用混合扫描仪进行FDGPET/CT扫描。PET/CT数据由经验丰富的核医学医师解释。该研究分析了FDGPET/CT对适当活检部位的指导，并评估了PET/CT发现与组织病理学检查之间的一致性。
结果：在573名患者中，219例患者最终确诊,包括恶性肿瘤,传染性原因,非感染性炎症原因（NIID），和癌前病变.FDGPET/CT在指导临床医生选择合适的活检部位中起着至关重要的作用。有助于更高的诊断产量。PET/CT发现与组织病理学检查之间的一致性强调了PET/CT在确定PUO的潜在原因方面的无创诊断潜力。总的来说,在50.05％的病例中，FDGPET/CT有助于指导活检的适当部位或首次鉴别诊断与最终诊断的一致性。
结论：这项研究强调了FDGPET/CT在提供诊断PUO的靶向方法方面的重要作用。展示了其在指导临床医生进行适当的活检部位和提高诊断率方面的潜力。这些发现强调了将FDGPET/CT整合到PUO诊断途径中的重要性，最终提高患者管理和结果。需要进一步的前瞻性研究来验证这些结果并完善FDGPET/CT在PUO诊断中的整合。
