Abstract：
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a rare and potentially life-threatening condition that may arise at any point during treatment and is often associated with adverse reactions to dopamine-blocking agents. This syndrome is normally characterized by features such as muscle rigidity, alteration in consciousness, autonomic instability, and leukocytosis.
OBJECTIVE: The aim of this study is to investigate a borderline intellectual functioning (BIF) case in which NMS with insidious disease progression and long prodromal symptoms was developed.
METHODS: The investigated patient was a 38-year-old female diagnosed with bipolar disorder and a variety of corresponding disorders. The patient exhibited gastrointestinal symptoms and restlessness in the weeks leading up to the study, subsequent to the administration of elevated doses of haloperidol, risperidone, and lithium. In addition, she was hospitalized for restlessness and aggressiveness in the summer of 2023. Furthermore, due to her chief complaint, she received parenteral haloperidol twice in the emergency room, subsequently experiencing fever, altered consciousness, generalized rigidity, and dysphagia. Moreover, the patient\'s initial creatine phosphokinase (CPK) level was 2550 IU/L, and she was hospitalized in an intensive care unit with the diagnosis of NMS for 8 days.
CONCLUSIONS: This case study highlights the necessity of being attentive about prodromal symptoms of NMS and emergent interventions.
OBJECTIVE: The aim of this study is to investigate a borderline intellectual functioning (BIF) case in which NMS with insidious disease progression and long prodromal symptoms was developed.
METHODS: The investigated patient was a 38-year-old female diagnosed with bipolar disorder and a variety of corresponding disorders. The patient exhibited gastrointestinal symptoms and restlessness in the weeks leading up to the study, subsequent to the administration of elevated doses of haloperidol, risperidone, and lithium. In addition, she was hospitalized for restlessness and aggressiveness in the summer of 2023. Furthermore, due to her chief complaint, she received parenteral haloperidol twice in the emergency room, subsequently experiencing fever, altered consciousness, generalized rigidity, and dysphagia. Moreover, the patient\'s initial creatine phosphokinase (CPK) level was 2550 IU/L, and she was hospitalized in an intensive care unit with the diagnosis of NMS for 8 days.
CONCLUSIONS: This case study highlights the necessity of being attentive about prodromal symptoms of NMS and emergent interventions.
摘要：
背景：抗精神病药恶性综合征（NMS）是一种罕见且可能危及生命的疾病，可在治疗过程中的任何时候出现，并且通常与多巴胺阻断剂的不良反应有关。这种综合征通常以肌肉僵硬等特征为特征，意识的改变，自主神经不稳定，和白细胞增多。
目的：本研究的目的是调查一个临界智力功能（BIF）病例，其中NMS具有隐匿性疾病进展和长期前驱症状。
方法：被调查的患者是一名38岁的女性，被诊断为双相情感障碍和各种相应的疾病。患者在研究前的几周内表现出胃肠道症状和躁动，在服用高剂量的氟哌啶醇之后，利培酮,和锂。此外,2023年夏天,她因烦躁不安和进取心而住院.此外，由于她的主要抱怨，她在急诊室接受了两次肠胃外氟哌啶醇，随后出现发烧，改变了意识,广义刚度，和吞咽困难.此外，患者的初始肌酸磷酸激酶（CPK）水平为2550IU/L，她在重症监护病房住院，诊断为NMS8天。
结论：本案例研究强调了关注NMS前驱症状和紧急干预措施的必要性。
目的：本研究的目的是调查一个临界智力功能（BIF）病例，其中NMS具有隐匿性疾病进展和长期前驱症状。
方法：被调查的患者是一名38岁的女性，被诊断为双相情感障碍和各种相应的疾病。患者在研究前的几周内表现出胃肠道症状和躁动，在服用高剂量的氟哌啶醇之后，利培酮,和锂。此外,2023年夏天,她因烦躁不安和进取心而住院.此外，由于她的主要抱怨，她在急诊室接受了两次肠胃外氟哌啶醇，随后出现发烧，改变了意识,广义刚度，和吞咽困难.此外，患者的初始肌酸磷酸激酶（CPK）水平为2550IU/L，她在重症监护病房住院，诊断为NMS8天。
结论：本案例研究强调了关注NMS前驱症状和紧急干预措施的必要性。
