PDF(Pubmed)
Abstract：
UNASSIGNED: Tumor budding (TB) has shown promising results as a prognostic marker in several cancers such as colorectal carcinoma, breast carcinoma etc. It has been co-related to aggressiveness of the tumor and can also predict the metastasis to the lymph nodes. This systematic review evaluates the prognostic potential of TB in predicting lymph node metastasis (LNM) in OSCC.
UNASSIGNED: Systematic search was carried out in the electronic data-bases i.e. PubMed, Cochrane and Google scholar for original studies related to TB in OSCC. The assessment of risk bias was done using QUIPS tool. Meta-analysis was done using STATA software.
UNASSIGNED: A total of 25 articles were included. A significant association was noted for overall survival and prognosis but not for TB LNM in OSCC. Meta-analysis revealed a pooled estimate i.e odds ratio of 2.10 (CI - 0.00 - 4.20) for TB and LNM while for overall survival, it was 2.29 (CI-1.81-2.76).
UNASSIGNED: Tumor budding though is strongly associated with LNM in OSCC did not show significant relationship in this systematic review but demonstrated a higher correlation with overall survival. It highlights that TB is an important parameter for prognosis of oral cancer but its potential in prediction of LNM needs further validation.
UNASSIGNED: Systematic search was carried out in the electronic data-bases i.e. PubMed, Cochrane and Google scholar for original studies related to TB in OSCC. The assessment of risk bias was done using QUIPS tool. Meta-analysis was done using STATA software.
UNASSIGNED: A total of 25 articles were included. A significant association was noted for overall survival and prognosis but not for TB LNM in OSCC. Meta-analysis revealed a pooled estimate i.e odds ratio of 2.10 (CI - 0.00 - 4.20) for TB and LNM while for overall survival, it was 2.29 (CI-1.81-2.76).
UNASSIGNED: Tumor budding though is strongly associated with LNM in OSCC did not show significant relationship in this systematic review but demonstrated a higher correlation with overall survival. It highlights that TB is an important parameter for prognosis of oral cancer but its potential in prediction of LNM needs further validation.
摘要：
■肿瘤出芽（TB）已显示出有希望的结果，可作为多种癌症（例如结直肠癌）的预后标志物，乳腺癌等.它与肿瘤的侵袭性相关，也可以预测淋巴结的转移。本系统综述评估了TB在预测OSCC淋巴结转移（LNM）中的预后潜力。
■在电子数据库中进行了系统搜索，即PubMed，Cochrane和Google学者在OSCC中与结核病相关的原始研究。使用QUIPS工具进行风险偏倚评估。采用STATA软件进行Meta分析。
■共包括25篇文章。OSCC中的TBLNM与总体生存率和预后之间存在显着关联，但与TBLNM无关。荟萃分析显示，结核病和LNM的比值比为2.10(CI-0.00-4.20)，而总生存率为，它是2.29（CI-1.81-2.76）。
■虽然肿瘤出芽与OSCC中的LNM密切相关，但在本系统评价中没有显示出显著的相关性，但与总生存期有更高的相关性。它强调了TB是口腔癌预后的重要参数，但其预测LNM的潜力需要进一步验证。
■在电子数据库中进行了系统搜索，即PubMed，Cochrane和Google学者在OSCC中与结核病相关的原始研究。使用QUIPS工具进行风险偏倚评估。采用STATA软件进行Meta分析。
■共包括25篇文章。OSCC中的TBLNM与总体生存率和预后之间存在显着关联，但与TBLNM无关。荟萃分析显示，结核病和LNM的比值比为2.10(CI-0.00-4.20)，而总生存率为，它是2.29（CI-1.81-2.76）。
■虽然肿瘤出芽与OSCC中的LNM密切相关，但在本系统评价中没有显示出显著的相关性，但与总生存期有更高的相关性。它强调了TB是口腔癌预后的重要参数，但其预测LNM的潜力需要进一步验证。
