PDF(Pubmed)
Abstract：
Skin wound healing is a complex and tightly regulated process. The frequent occurrence and reoccurrence of acute and chronic wounds cause significant skin damage to patients and impose socioeconomic burdens. Therefore, there is an urgent requirement to promote interdisciplinary development in the fields of material science and medicine to investigate novel mechanisms for wound healing. Cerium oxide nanoparticles (CeO2 NPs) are a type of nanomaterials that possess distinct properties and have broad application prospects. They are recognized for their capabilities in enhancing wound closure, minimizing scarring, mitigating inflammation, and exerting antibacterial effects, which has led to their prominence in wound care research. In this paper, the distinctive physicochemical properties of CeO2 NPs and their most recent synthesis approaches are discussed. It further investigates the therapeutic mechanisms of CeO2 NPs in the process of wound healing. Following that, this review critically examines previous studies focusing on the effects of CeO2 NPs on wound healing. Finally, it suggests the potential application of cerium oxide as an innovative nanomaterial in diverse fields and discusses its prospects for future advancements.
摘要：
皮肤伤口愈合是一个复杂且严格调控的过程。急性和慢性伤口的频繁发生和复发对患者造成显著的皮肤损伤并施加社会经济负担。因此,迫切需要促进材料科学和医学领域的跨学科发展，以研究伤口愈合的新机制。氧化铈纳米粒子(CeO2NPs)是一类性质独特的纳米材料,具有广阔的应用前景。它们因其增强伤口闭合的能力而被认可，尽量减少疤痕，缓解炎症，发挥抗菌作用，这导致了他们在伤口护理研究中的突出地位。在本文中,讨论了CeO2NPs独特的物理化学性质及其最新的合成方法。它进一步研究了CeO2NPs在伤口愈合过程中的治疗机制。在此之后,这篇综述严格审查了以前的研究集中在CeO2NPs对伤口愈合的影响。最后,它提出了氧化铈作为创新纳米材料在不同领域的潜在应用，并讨论了其未来发展的前景。
