PDF(Pubmed)
Abstract：
Full-thickness skin graft (FTSG) reconstructions of lower limbs are especially prone to wound complications. Negative pressure wound therapy (NPWT) enhances wound healing, but no broad evidence exists if it promotes graft take of lower leg FTSGs. In this investigator-initiated, prospective, randomised and controlled trial, 20 patients with ambulatory FTSG reconstruction for lower limb skin cancers were randomised for postoperative treatment with either NPWT, or conventional dressings. As outcomes, adherence of the skin graft 1 week postoperatively, any wound complications within 3 months, including ≥3 weeks delayed wound healing, and the number of additional postoperative visits were compared. In both groups, grafts adhered equally well (p = 0.47); 80% of NPWT-treated and 100% of control group grafts adhered >90%. There was no significant difference in the number of postoperative complications/delayed wound healing (p = 0.65); 70% of patients in the NPWT and 50% in the control group developed a wound complication. Both groups had an equal number of patients with at least three additional control visits (p = 1.0). The study was discontinued after 20 patients were recruited, as no benefit from NPWT was seen. To conclude, the study showed no benefit from NPWT for lower limb FTSGs.
摘要：
下肢全层皮肤移植（FTSG）重建特别容易发生伤口并发症。负压伤口治疗（NPWT）可促进伤口愈合，但如果它能促进小腿FTSGs的移植，则没有广泛的证据存在。在这个调查员发起的，prospective,随机对照试验，20例下肢皮肤癌的动态FTSG重建患者随机接受NPWT的术后治疗，或常规敷料。作为结果，术后1周皮肤移植的粘连，3个月内任何伤口并发症，包括≥3周的伤口延迟愈合，并比较了额外的术后访视次数。在这两组中,移植物粘附同样良好(p=0.47);80%的NPWT处理的移植物和100%的对照组移植物粘附>90%。术后并发症/伤口延迟愈合的数量没有显着差异（p=0.65）；NPWT中70％的患者和对照组中50％的患者出现了伤口并发症。两组患者的数量相等，至少有3次其他对照访问（p=1.0）。这项研究在招募了20名患者后停止，因为没有看到NPWT的好处。最后，研究显示,NPWT对下肢FTSG无益处.
