Abstract：
OBJECTIVE: The populational impact of poor sleep quality and the risk of dementia is unclear. We analyzed the Population Attributable Fraction (PAF) of poor sleep quality for dementia, and its association with other two sleep parameters through self-reported and single questions collected in a large-scale Brazilian cohort (ELSI-Brazil).
METHODS: A subset of the ELSI-Brazil with complete responses to sleep quality was retrieved for this study. This is a large representative sample of the Brazilian elderly population with an extensive assessment of sociodemographic and health risk variables. Prevalence of poor sleep quality was estimated according to the complex sample design, and its PAF was measured using a meta-analytic relative risk. A total of 6024 (56.3% women, mean 62.8 ± 9.5 years of age) individuals had complete responses.
RESULTS: The prevalence of poor sleep quality was 24.9% (95%CI 23%-26%), and the PAF of poor sleep quality including other 10 modifiable risk factors of dementia was 52.5% in Brazil. Secondary analyses identified that sleep quality, restorative sleep and sleep drug usage varied considerably according to age ranges, race, and gender.
CONCLUSIONS: Poor sleep quality is an important populational modifiable risk factor for dementia in Brazil. Targeted interventions may provide an important impact in preventing dementia in low- and middle-income countries.
METHODS: A subset of the ELSI-Brazil with complete responses to sleep quality was retrieved for this study. This is a large representative sample of the Brazilian elderly population with an extensive assessment of sociodemographic and health risk variables. Prevalence of poor sleep quality was estimated according to the complex sample design, and its PAF was measured using a meta-analytic relative risk. A total of 6024 (56.3% women, mean 62.8 ± 9.5 years of age) individuals had complete responses.
RESULTS: The prevalence of poor sleep quality was 24.9% (95%CI 23%-26%), and the PAF of poor sleep quality including other 10 modifiable risk factors of dementia was 52.5% in Brazil. Secondary analyses identified that sleep quality, restorative sleep and sleep drug usage varied considerably according to age ranges, race, and gender.
CONCLUSIONS: Poor sleep quality is an important populational modifiable risk factor for dementia in Brazil. Targeted interventions may provide an important impact in preventing dementia in low- and middle-income countries.
摘要：
目的：睡眠质量差和痴呆风险对人群的影响尚不清楚。我们分析了痴呆症睡眠质量差的人群归因分数(PAF)，通过在大规模巴西队列（ELSI-Brazil）中收集的自我报告和单个问题，以及其与其他两个睡眠参数的关联。
方法：本研究检索了ELSI-巴西对睡眠质量有完全反应的子集。这是巴西老年人口的大量代表性样本，对社会人口统计学和健康风险变量进行了广泛评估。根据复杂的样本设计估计睡眠质量差的患病率，并使用荟萃分析相对风险来测量其PAF。共6024人(56.3%为女性,平均62.8±9.5岁）的个体有完全反应。
结果：睡眠质量差的患病率为24.9%（95CI23%-26%），在巴西，睡眠质量差（包括其他10个可改变的痴呆危险因素）的PAF为52.5%。次要分析确定睡眠质量，恢复性睡眠和睡眠药物的使用根据年龄范围有很大差异，种族,和性别。
结论：睡眠质量差是巴西痴呆的一个重要的可改变的危险因素。有针对性的干预措施可能对预防低收入和中等收入国家的痴呆症产生重要影响。
方法：本研究检索了ELSI-巴西对睡眠质量有完全反应的子集。这是巴西老年人口的大量代表性样本，对社会人口统计学和健康风险变量进行了广泛评估。根据复杂的样本设计估计睡眠质量差的患病率，并使用荟萃分析相对风险来测量其PAF。共6024人(56.3%为女性,平均62.8±9.5岁）的个体有完全反应。
结果：睡眠质量差的患病率为24.9%（95CI23%-26%），在巴西，睡眠质量差（包括其他10个可改变的痴呆危险因素）的PAF为52.5%。次要分析确定睡眠质量，恢复性睡眠和睡眠药物的使用根据年龄范围有很大差异，种族,和性别。
结论：睡眠质量差是巴西痴呆的一个重要的可改变的危险因素。有针对性的干预措施可能对预防低收入和中等收入国家的痴呆症产生重要影响。
