关键词: RANK RANK-L bone tumors chondroblastoma denosumab metastasis

Mesh : Humans Male Bone Neoplasms / secondary drug therapy Lung Neoplasms / secondary drug therapy pathology Denosumab / therapeutic use Chondroblastoma / drug therapy Young Adult Humerus / pathology Bone Density Conservation Agents / therapeutic use

来  源:   DOI:10.15537/smj.2024.45.6.20230720   PDF(Pubmed)

Abstract:
Chondroblastoma is a rare benign cartilaginous tumor that accounts for approximately 1% of bone tumors, but it can be associated with lung metastasis in extremely rare cases, leading to a poor prognosis and death. Herein, we report the case of a 19-year-old male patient who presented with an aggressive chondroblastoma of the proximal humerus and bilateral lung metastasis. The patient was treated with wide local resection, partial metastasectomy, and denosumab. Denosumab treatment was effective in controlling metastatic progression and preventing local recurrence.
摘要:
软骨母细胞瘤是一种罕见的良性软骨肿瘤,约占骨肿瘤的1%。但在极少数情况下,它可能与肺转移有关,导致预后不良和死亡。在这里,我们报道了一例19岁男性患者,表现为侵袭性肱骨近端软骨母细胞瘤和双侧肺转移.患者接受了广泛的局部切除术,部分转移瘤切除术,还有Denosumab.Denosumab治疗可有效控制转移进展并预防局部复发。
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