Abstract：
OBJECTIVE: Children\'s of Mississippi at the University of Mississippi Medical Center serves as the state\'s only American Cleft Palate-Craniofacial Association-approved cleft team at the only pediatric hospital in the state. The goal of this study is to report geographic and demographic patterns of patients with orofacial cleft (OFC) treated at Children\'s of Mississippi, which are lacking.
METHODS: Patients with OFC treated at Children\'s of Mississippi from 2015 to 2020 were included. Demographic data were collected, including birth county and total live births from state data. Significant differences between incidence of OFC among public health regions of Mississippi were examined using analysis of variance (P < 0.05). Cases were compared with historical data from 1980 to 1989.
RESULTS: There were 184 patients who presented with OFC, with a statewide incidence of 0.83 per 1000 live births among 222,819 live births in the state across 6 years. The incidence of OFC was 0.83/1000 for Whites and 0.82/1000 for non-Whites versus a historical rate of 1.36 and 0.54, respectively. Significantly fewer children in the northern region (0.25/1000) were born with OFC than in central (1.21; P < 0.001) and southern (0.86; P < 0.001) regions.
CONCLUSIONS: Results from this study suggest changing regional patterns of OFC in Mississippi. Although rates increased among non-White infants, the overall incidence of OFC has decreased compared with historical data. The findings may reflect actual incidence patterns in the state or the proximity of certain regions to Children\'s of Mississippi. Further study may reveal regional differences in risk factors underlying OFC incidence, and/or issues with access to cleft care for different regions in the state.
METHODS: Patients with OFC treated at Children\'s of Mississippi from 2015 to 2020 were included. Demographic data were collected, including birth county and total live births from state data. Significant differences between incidence of OFC among public health regions of Mississippi were examined using analysis of variance (P < 0.05). Cases were compared with historical data from 1980 to 1989.
RESULTS: There were 184 patients who presented with OFC, with a statewide incidence of 0.83 per 1000 live births among 222,819 live births in the state across 6 years. The incidence of OFC was 0.83/1000 for Whites and 0.82/1000 for non-Whites versus a historical rate of 1.36 and 0.54, respectively. Significantly fewer children in the northern region (0.25/1000) were born with OFC than in central (1.21; P < 0.001) and southern (0.86; P < 0.001) regions.
CONCLUSIONS: Results from this study suggest changing regional patterns of OFC in Mississippi. Although rates increased among non-White infants, the overall incidence of OFC has decreased compared with historical data. The findings may reflect actual incidence patterns in the state or the proximity of certain regions to Children\'s of Mississippi. Further study may reveal regional differences in risk factors underlying OFC incidence, and/or issues with access to cleft care for different regions in the state.
摘要：
目的：密西西比州大学医学中心的密西西比州儿童是该州唯一的美国唇裂-颅面协会批准的唇裂团队，是该州唯一的儿科医院。这项研究的目的是报告在密西西比州儿童治疗的口面裂（OFC）患者的地理和人口统计学模式，缺乏的。
方法：纳入2015年至2020年密西西比州儿童接受OFC治疗的患者。收集了人口统计数据，包括出生县和来自州数据的活产总数。使用方差分析检查密西西比州公共卫生地区OFC发病率之间的显着差异（P<0.05）。病例与1980年至1989年的历史数据进行了比较。
结果：184例OFC患者，在6年内，全州范围内的222,819例活产婴儿中，每1000例活产婴儿中有0.83例。白人的OFC发生率为0.83/1000，非白人为0.82/1000，历史比率分别为1.36和0.54。北部地区（0.25/1000）出生的OFC儿童明显少于中部地区（1.21;P<0.001）和南部地区（0.86;P<0.001）。
结论：这项研究的结果表明密西西比州OFC的区域模式正在发生变化。尽管非白人婴儿的比率有所增加，OFC的总体发病率与历史数据相比有所下降.这些发现可能反映了密西西比州儿童的州或某些地区附近的实际发病率模式。进一步的研究可能揭示OFC发病率潜在危险因素的地区差异，和/或该州不同地区获得裂隙护理的问题。
方法：纳入2015年至2020年密西西比州儿童接受OFC治疗的患者。收集了人口统计数据，包括出生县和来自州数据的活产总数。使用方差分析检查密西西比州公共卫生地区OFC发病率之间的显着差异（P<0.05）。病例与1980年至1989年的历史数据进行了比较。
结果：184例OFC患者，在6年内，全州范围内的222,819例活产婴儿中，每1000例活产婴儿中有0.83例。白人的OFC发生率为0.83/1000，非白人为0.82/1000，历史比率分别为1.36和0.54。北部地区（0.25/1000）出生的OFC儿童明显少于中部地区（1.21;P<0.001）和南部地区（0.86;P<0.001）。
结论：这项研究的结果表明密西西比州OFC的区域模式正在发生变化。尽管非白人婴儿的比率有所增加，OFC的总体发病率与历史数据相比有所下降.这些发现可能反映了密西西比州儿童的州或某些地区附近的实际发病率模式。进一步的研究可能揭示OFC发病率潜在危险因素的地区差异，和/或该州不同地区获得裂隙护理的问题。
