Abstract：
Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses.
摘要：
大麻长期以来一直用于神经和心理治疗。最近,从大麻sativa中提取的大麻二酚（CBD）由于其对中枢和周围神经系统的非精神治疗作用而在医学领域中占有重要地位。CBD,也是一种有效的抗氧化剂，显示不同的临床特性，如抗癌，抗炎,抗抑郁药,抗氧化剂，止吐药,抗焦虑药,抗癫痫药,和抗精神病药物的作用。在这次审查中,我们通过实验和计算技术总结了CBD与不同受体的结构活性关系，并研究了相关受体与CBD相互作用的机制。CBD与靶受体结构活性关系的发现将为CBD及其衍生物支架的优化提供方向。这将为各种疾病提供基于CBD的疗法的潜在医学应用。
