Abstract：
OBJECTIVE: We performed the study to investigate the association between heart rate (HR) non-dipping pattern and target organ damage in patients with chronic kidney disease (CKD) and hypertension.
METHODS: In this cross-sectional study, 447 patients with CKD and hypertension were enrolled. 24 h ambulatory blood pressure monitoring was conducted. Linear regression and logistic regression analysis were conducted to investigate the association between HR non-dipping pattern and target organ damage, including estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), and left ventricular hypertrophy (LVH).
RESULTS: Overall, 261 patients (58.4%) followed non-dipping patterns of HR. HR non-dipping pattern remained to be significantly associated with reduced eGFR (β: -0.384; 95% CI: -0.719 to -0.050; p = 0.025) and the higher prevalence of CKD stages 4-5 (OR: 2.141; 95% CI: 1.153 to 3.977; p = 0.016). Meanwhile, HR non-dipping pattern was independently associated with LVMI (β: 0.021; 95% CI: 0.000 to 0.041; p = 0.049) and LVH (OR: 1.78; 95% CI: 1.07 to 2.96; p = 0.027) after adjusting for confounding factors.
CONCLUSIONS: HR non-dipping pattern was independently associated with impaired renal function and cardiac damage. Non-dipping HR deserves further attention and needs to be detected and treated during the management of CKD patients.
METHODS: In this cross-sectional study, 447 patients with CKD and hypertension were enrolled. 24 h ambulatory blood pressure monitoring was conducted. Linear regression and logistic regression analysis were conducted to investigate the association between HR non-dipping pattern and target organ damage, including estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), and left ventricular hypertrophy (LVH).
RESULTS: Overall, 261 patients (58.4%) followed non-dipping patterns of HR. HR non-dipping pattern remained to be significantly associated with reduced eGFR (β: -0.384; 95% CI: -0.719 to -0.050; p = 0.025) and the higher prevalence of CKD stages 4-5 (OR: 2.141; 95% CI: 1.153 to 3.977; p = 0.016). Meanwhile, HR non-dipping pattern was independently associated with LVMI (β: 0.021; 95% CI: 0.000 to 0.041; p = 0.049) and LVH (OR: 1.78; 95% CI: 1.07 to 2.96; p = 0.027) after adjusting for confounding factors.
CONCLUSIONS: HR non-dipping pattern was independently associated with impaired renal function and cardiac damage. Non-dipping HR deserves further attention and needs to be detected and treated during the management of CKD patients.
摘要：
目的：本研究旨在探讨慢性肾脏病（CKD）合并高血压患者心率（HR）非浸渍模式与靶器官损害之间的关系。
方法：在这项横断面研究中，纳入447例CKD和高血压患者。进行24h动态血压监测。进行线性回归和logistic回归分析，以探讨HR非浸渍模式与靶器官损害之间的关系。包括估计的肾小球滤过率(eGFR)，左心室质量指数(LVMI),左心室肥厚(LVH)。
结果：总体而言，261例患者（58.4%）遵循非浸渍型HR。HR非浸渍模式仍然与eGFR降低(β:-0.384;95%CI:-0.719至-0.050;p=0.025)和CKD4-5期患病率较高(OR:2.141;95%CI:1.153至3.977;p=0.016)显著相关。同时,校正混杂因素后，HR非浸渍模式与LVMI(β:0.021;95%CI:0.000~0.041;p=0.049)和LVH(OR:1.78;95%CI:1.07~2.96;p=0.027)独立相关。
结论：HR非浸渍模式与肾功能受损和心脏损害独立相关。非浸渍HR值得进一步关注，需要在CKD患者的管理过程中进行检测和治疗。
方法：在这项横断面研究中，纳入447例CKD和高血压患者。进行24h动态血压监测。进行线性回归和logistic回归分析，以探讨HR非浸渍模式与靶器官损害之间的关系。包括估计的肾小球滤过率(eGFR)，左心室质量指数(LVMI),左心室肥厚(LVH)。
结果：总体而言，261例患者（58.4%）遵循非浸渍型HR。HR非浸渍模式仍然与eGFR降低(β:-0.384;95%CI:-0.719至-0.050;p=0.025)和CKD4-5期患病率较高(OR:2.141;95%CI:1.153至3.977;p=0.016)显著相关。同时,校正混杂因素后，HR非浸渍模式与LVMI(β:0.021;95%CI:0.000~0.041;p=0.049)和LVH(OR:1.78;95%CI:1.07~2.96;p=0.027)独立相关。
结论：HR非浸渍模式与肾功能受损和心脏损害独立相关。非浸渍HR值得进一步关注，需要在CKD患者的管理过程中进行检测和治疗。
