%0 Journal Article
%T The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease.
%A Zhou H
%A Dong L
%A Liu X
%A Li F
%A Tang Y
%A Qin W
%J Int Urol Nephrol
%V 0
%N 0
%D 2024 Jun 3
%M 38829465
%F 2.266
%R 10.1007/s11255-024-04095-5
%X <B>OBJECTIVE: </B>We performed the study to investigate the association between heart rate (HR) non-dipping pattern and target organ damage in patients with chronic kidney disease (CKD) and hypertension.<BR><B>METHODS: </B>In this cross-sectional study, 447 patients with CKD and hypertension were enrolled. 24 h ambulatory blood pressure monitoring was conducted. Linear regression and logistic regression analysis were conducted to investigate the association between HR non-dipping pattern and target organ damage, including estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), and left ventricular hypertrophy (LVH).<BR><B>RESULTS: </B>Overall, 261 patients (58.4%) followed non-dipping patterns of HR. HR non-dipping pattern remained to be significantly associated with reduced eGFR (β: -0.384; 95% CI: -0.719 to -0.050; p = 0.025) and the higher prevalence of CKD stages 4-5 (OR: 2.141; 95% CI: 1.153 to 3.977; p = 0.016). Meanwhile, HR non-dipping pattern was independently associated with LVMI (β: 0.021; 95% CI: 0.000 to 0.041; p = 0.049) and LVH (OR: 1.78; 95% CI: 1.07 to 2.96; p = 0.027) after adjusting for confounding factors.<BR><B>CONCLUSIONS: </B>HR non-dipping pattern was independently associated with impaired renal function and cardiac damage. Non-dipping HR deserves further attention and needs to be detected and treated during the management of CKD patients.