PDF(Pubmed)
Abstract：
Fracture repair is a constant clinical challenge, and finding a method to promote and improve restoration is a primary goal for researchers. This is examined from various perspectives, such as fewer complications, increased speed, and cost-effectiveness. The present study aimed to investigate the effectiveness of eggshell powder, compared to the commercial form of demineralized bone matrix (DBM), in critical-size defects in rat calvarial bone. In this study, 40 adult male Wistar rats were selected and randomly divided into four groups of 10. The first group was the control group (C), the second was the eggshell powder group (E), the third was the DBM group (D), and the fourth was the one simultaneously receiving eggshell powder and DBM (DE). In these groups, a 5 mm diameter defect was created in the calvaria using a trephine. All animals received the appropriate treatment for their group. Each group was then divided into two subgroups of five. On days 30 and 60 post-surgery, these subgroups were euthanized, followed by sampling and histopathology examinations. After evaluating the repair percentage using Quick Photo software, the DE group had the highest repair percentage on days 30 and 60. Groups E and D had similar recovery percentages, with group D having a slightly higher one. There was a significant difference between all three groups and the control group. In conclusion, eggshell powder may potentially serve as a suitable substitute for some transplants.
摘要：
骨折修复是一个不断的临床挑战，找到促进和改善恢复的方法是研究人员的首要目标。这是从不同的角度来考察的，例如更少的并发症，提高速度,和成本效益。本研究旨在研究蛋壳粉的有效性，与商业形式的去矿质骨基质(DBM)相比，大鼠颅骨的临界尺寸缺陷。在这项研究中,选用成年雄性Wistar年夜鼠40只，随机分为四组10只。第一组为对照组(C),第二个是蛋壳粉组（E），第三个是DBM组(D)，第四个是同时接收蛋壳粉和DBM(DE)的那个。在这些群体中,使用环钻在颅骨中产生了5毫米直径的缺陷。所有动物都接受了它们组的适当治疗。然后将每组分为五个一组的两个亚组。手术后第30天和第60天,这些亚组被安乐死，然后进行取样和组织病理学检查。使用QuickPhoto软件评估维修百分比后，DE组在第30天和第60天的修复率最高。E组和D组有相似的恢复百分比，D组有一个略高的。三组与对照组之间存在显著差异。总之,蛋壳粉可能作为一些移植的合适替代品。
