Abstract：
The recognition of constipation as a possible non-Immunoglobulin E (IgE)-mediated allergic condition is challenging because functional constipation (unrelated to food allergies) is a common health problem with a reported worldwide prevalence rate of up to 32.2% in children. However, many studies in children report challenge proven cow\'s milk allergy and constipation as a primary symptom and have found that between 28% and 78% of children improve on a cow\'s milk elimination diet. Due to the paucity of data and a focus on IgE-mediated allergy, not all food allergy guidelines list constipation as a symptom of food allergy. Yet, it is included in all cow\'s milk allergy guidelines available in English language. The Exploring Non-IgE-Mediated Allergy (ENIGMA) Task Force (TF) of the European Academy for Allergy and Clinical Immunology (EAACI) considers in this paper constipation in the context of failure of standard treatment and discuss the role of food allergens as culprit in constipation in children. This position paper used the Delphi approach in reaching consensus on both diagnosis and management, as currently published data are insufficient to support a systematic review.
摘要：
将便秘识别为可能的非免疫球蛋白E（IgE）介导的过敏性疾病具有挑战性，因为功能性便秘（与食物过敏无关）是常见的健康问题，据报道，全球儿童患病率高达32.2％。然而,许多儿童研究报告说，挑战证明牛奶过敏和便秘是主要症状，并发现28％至78％的儿童改善了牛奶消除饮食。由于缺乏数据和关注IgE介导的过敏，并非所有食物过敏指南都将便秘列为食物过敏的症状。然而，它包含在所有牛奶过敏指南中以英语提供。欧洲过敏和临床免疫学学会（EAACI）的非IgE介导的过敏（ENIGMA）探索工作组（TF）在本文中认为，在标准治疗失败的情况下便秘，并讨论食物过敏原作为儿童便秘的罪魁祸首。这篇立场论文使用德尔菲方法在诊断和管理方面达成共识，因为目前公布的数据不足以支持系统审查。
