PDF(Pubmed)
Abstract：
Antimicrobial surfaces limit the spread of infectious diseases. To date, there is no antimicrobial coating that has widespread use because of short-lived and limited spectrum efficacy, poor resistance to organic material, and/or cost. Here, we present a paint based on waterborne latex particles that is supramolecularly associated with quaternary ammonium compounds (QACs). The optimal supramolecular pairing was first determined by immobilizing selected ions on self-assembled monolayers exposing different groups. The QAC surface loading density was then increased by using polymer brushes. These concepts were adopted to develop inexpensive paints to be applied on many different surfaces. The paint could be employed for healthcare and food production applications. Its slow release of QAC allows for long-lasting antimicrobial action, even in the presence of organic material. Its efficacy lasts for more than 90 washes, and importantly, once lost, it can readily be restored by spraying an aqueous solution of the QAC. We mainly tested cetyltrimethylammonium as QAC as it is already used in consumer care products. Our antimicrobial paint is broad spectrum as it showed excellent antimicrobial efficiency against four bacteria and four viruses.
摘要：
抗菌表面限制了传染病的传播。迄今为止,没有抗菌涂层，具有广泛使用，因为短寿命和有限的光谱功效，对有机材料的抵抗力差，和/或成本。这里,我们提出了一种基于与季铵化合物（QAC）超分子缔合的水性乳胶颗粒的涂料。最佳的超分子配对首先通过将选择的离子固定在暴露不同基团的自组装单层上来确定。然后通过使用聚合物刷增加QAC表面负载密度。采用这些概念来开发将应用于许多不同表面上的廉价涂料。该涂料可用于医疗保健和食品生产应用。QAC的缓慢释放允许持久的抗菌作用，即使在有机物质的存在。它的功效持续90多次洗涤，而且重要的是,一旦丢失,它可以很容易地通过喷洒QAC的水溶液来恢复。我们主要测试十六烷基三甲基铵作为QAC，因为它已经用于消费者护理产品。我们的抗菌涂料是广谱的，因为它对四种细菌和四种病毒表现出优异的抗菌效率。
