Abstract：
Controlling the morphology of molecular assemblies formed by surfactants by photoirradiation enables the controlled release of incorporated substances, which can be applied to delivery systems for drugs and active ingredients. On the other hand, conventional photoresponsive surfactants and molecular assemblies have a slow response speed, making it difficult to control their functions at the desired time. In this review, I discuss our recent progress in the accelerated control of functions of photoresponsive molecular assemblies by using lophine dimer as a photochromic compound. The lophine dimer derivative dissociates into a pair of lophyl radicals that upon ultraviolet (UV) light irradiation, and these radical species thermally recombine although the recombination reaction is extremely slow due to the diffusion of lophyl radicals. By using the confined inner space of micelles formed by surfactants, the recombination reaction was extremely accelerated. With UV light irradiation, rapid morphological changes in micelles, formed by amphiphilic lophine dimers were observed by using in situ small-angle neutron scattering (in situ SANS) system. Moreover, the rapid controlled release of calcein as a model drug was achieved by UV light irradiation using the photoresponsive micelles. This rapid system can realize the controlled release of drugs truly at the desired time, developing an efficient and precise drug delivery system (DDS). Furthermore, it can be applied in a wide range of fields such as release control of active ingredients, efficient heat exchange control, and actuating systems.
摘要：
通过光辐射控制由表面活性剂形成的分子组装体的形态，能够控制掺入物质的释放，可应用于药物和活性成分的递送系统。另一方面,传统的光响应表面活性剂和分子组装体的响应速度慢,使其难以在期望的时间控制其功能。在这次审查中,我讨论了通过使用洛芬二聚体作为光致变色化合物来加速控制光敏分子组装体功能的最新进展。在紫外线（UV）照射下，洛芬二聚体衍生物解离成一对环磷酰自由基，这些自由基物质热重组，尽管重组反应由于环磷酰自由基的扩散而极其缓慢。通过利用表面活性剂形成的胶束的有限内部空间，重组反应极度加速。用紫外线照射，胶束的快速形态变化，通过使用原位小角度中子散射（原位SANS）系统观察到由两亲性洛芬二聚体形成的二聚体。此外，通过使用光敏胶束的紫外线照射，实现了钙黄绿素作为模型药物的快速控制释放。这种快速系统可以在所需时间真正实现药物的控制释放，开发高效精确的药物输送系统（DDS）。此外，它可以应用于广泛的领域，如活性成分的释放控制，高效的热交换控制，和驱动系统。
