Abstract：
OBJECTIVE: This report aimed to describe mortality at 18 months in older survivors of the first wave of COVID-19.
METHODS: Observational cohort study.
METHODS: Patients aged ≥65 years hospitalized for COVID-19 in the acute geriatric wards of 2 centers.
METHODS: Characteristics of deceased and survivors were compared by Fisher exact, Mann-Whitney U, or 2-tailed t tests. Survival rates were analysed by Cox proportional hazards regression models.
RESULTS: Of a total of 323 patients admitted during the first wave, 196 survived the acute phase, with 34 patients who died in the 18 months after hospital discharge (17.3%). Higher mortality was observed in patients living in nursing homes (P = .033) and in those who were hospitalized after discharge during the follow-up period (97.1% vs 72.8%, P = .001). There was no difference in survival curves according to age, sex, presence of dyspnea, and dementia. Living in a nursing home significantly increased the mortality rates in the multivariate model adjusted for age and sex (hazard ratio 3.07, 95% CI 1.47-6.40; P = .007).
CONCLUSIONS: No excess mortality was observed during 18 months in older survivors of COVID-19. Living in a nursing home was associated with decreased survival rates.
METHODS: Observational cohort study.
METHODS: Patients aged ≥65 years hospitalized for COVID-19 in the acute geriatric wards of 2 centers.
METHODS: Characteristics of deceased and survivors were compared by Fisher exact, Mann-Whitney U, or 2-tailed t tests. Survival rates were analysed by Cox proportional hazards regression models.
RESULTS: Of a total of 323 patients admitted during the first wave, 196 survived the acute phase, with 34 patients who died in the 18 months after hospital discharge (17.3%). Higher mortality was observed in patients living in nursing homes (P = .033) and in those who were hospitalized after discharge during the follow-up period (97.1% vs 72.8%, P = .001). There was no difference in survival curves according to age, sex, presence of dyspnea, and dementia. Living in a nursing home significantly increased the mortality rates in the multivariate model adjusted for age and sex (hazard ratio 3.07, 95% CI 1.47-6.40; P = .007).
CONCLUSIONS: No excess mortality was observed during 18 months in older survivors of COVID-19. Living in a nursing home was associated with decreased survival rates.
摘要：
目的：本报告旨在描述第一波COVID-19年龄较大的幸存者在18个月时的死亡率。
方法：观察性队列研究。
方法：2个中心的急性老年病房因COVID-19住院的年龄≥65岁患者。
方法：通过Fisher精确比较死者和幸存者的特征，Mann-WhitneyU,或双尾t检验。采用Cox比例风险回归模型分析生存率。
结果：在第一波期间共收治323名患者中，196在急性期幸存下来，34例患者在出院后18个月内死亡（17.3%）。在疗养院（P=0.033）和在随访期间出院后住院的患者中观察到更高的死亡率（97.1％vs72.8％，P=.001)。根据年龄，存活曲线没有差异，性别,呼吸困难的存在，和痴呆症。在调整了年龄和性别的多变量模型中，生活在疗养院中的死亡率显着增加（风险比3.07，95％CI1.47-6.40；P=.007）。
结论：在COVID-19的老年幸存者中，在18个月内没有观察到超额死亡率。生活在疗养院与生存率下降有关。
方法：观察性队列研究。
方法：2个中心的急性老年病房因COVID-19住院的年龄≥65岁患者。
方法：通过Fisher精确比较死者和幸存者的特征，Mann-WhitneyU,或双尾t检验。采用Cox比例风险回归模型分析生存率。
结果：在第一波期间共收治323名患者中，196在急性期幸存下来，34例患者在出院后18个月内死亡（17.3%）。在疗养院（P=0.033）和在随访期间出院后住院的患者中观察到更高的死亡率（97.1％vs72.8％，P=.001)。根据年龄，存活曲线没有差异，性别,呼吸困难的存在，和痴呆症。在调整了年龄和性别的多变量模型中，生活在疗养院中的死亡率显着增加（风险比3.07，95％CI1.47-6.40；P=.007）。
结论：在COVID-19的老年幸存者中，在18个月内没有观察到超额死亡率。生活在疗养院与生存率下降有关。
