Abstract：
Oleic acid (OA) is a monounsaturated compound with many health-benefitting properties such as obesity prevention, increased insulin sensitivity, antihypertensive and immune-boosting properties, etc. The aim of this study was to analyze the effect of oleic acid (OA) and some anticancer drugs against oxidative damage induced by nitropropionic acid (NPA) in rat brain. Six groups of Wistar rats were treated as follows: Group 1, (control); group 2, OA; group 3, NPA + OA; group 4, cyclophosphamide (CPP) + OA; group 5, daunorubicin (DRB) + OA; and group 6, dexrazoxane (DXZ) + OA. All compounds were administered intraperitoneally route, every 24 h for 5 days. Their brains were extracted to measure lipoperoxidation (TBARS), H2O2, Ca+2, Mg+2 ATPase activity, glutathione (GSH) and dopamine. Glucose, hemoglobin and triglycerides were measured in blood. In cortex GSH increased in all groups, except in group 2, the group 4 showed the highest increase of this biomarker. TBARS decrease, and dopamine increase in all regions of groups 4, 5 and 6. H2O2 increased only in cerebellum/medulla oblongata of group 5 and 6. ATPase expression decreased in striatum of group 4. Glucose increased in group 6, and hemoglobin increased in groups 4 and 5. These results suggest that the increase of dopamine and the antioxidant effect of oleic acid administration during treatment with oncologic agents could result in less brain injury.
摘要：
油酸（OA）是一种单不饱和化合物，具有许多有益于健康的特性，如预防肥胖，胰岛素敏感性增加，抗高血压和免疫增强特性，等。本研究的目的是分析油酸（OA）和一些抗癌药物对大鼠脑组织中硝基丙酸（NPA）引起的氧化损伤的作用。对6组Wistar大鼠进行如下处理:第1组(对照);第2组,OA;第3组,NPA+OA;第4组,环磷酰胺(CPP)+OA;第5组,柔红霉素(DRB)+OA;和第6组,右雷唑烷(DXZ)+OA。所有化合物均通过腹膜内途径给药，每24小时5天。他们的大脑被提取来测量脂过氧化(TBARS)，H2O2、Ca+2、Mg+2ATP酶活性,谷胱甘肽（GSH）和多巴胺。葡萄糖,测量血液中的血红蛋白和甘油三酯。在皮质中，GSH在所有组中都增加，除第2组外,第4组显示该生物标志物的增加最高.TBARS减少,4、5和6组所有区域的多巴胺增加。H2O2仅在第5组和第6组的小脑/延髓中增加。4组纹状体中ATPase表达降低。第6组的葡萄糖增加，第4组和第5组的血红蛋白增加。这些结果表明，在用肿瘤药物治疗期间，多巴胺的增加和油酸的抗氧化作用可以减少脑损伤。
