Abstract：
Loneliness and related constructs associated with isolation are public health problems with increasing prevalence. The aim of this umbrella was to collate and grade evidence analyzing actual and subjective loneliness as a health risk factor. Following prospective registration, a systematic search was conducted in Pubmed, Embase, Scopus, Web of Sciences, psycoINFO and Cochrane Library until August 2023. Systematic reviews assessing the association between actual and subjective loneliness with adverse health outcomes were selected. Risk of bias was evaluated using AMSTAR-2 tool. Data were tabulated and synthesis was narrative. A total of 13 systematic reviews was selected (four included meta-analysis). The methodological quality was critically low in 10 reviews (76.92%) and low in 3 (23.08%). Results showed that loneliness was related to poor well-being and increase the risk of negative mental and physical health. The available data suggested but did not allow the confirmation of a causal association. Most constructs of loneliness seem to be related to mental and physical health conditions. A preventive strategy ought to be recommended, especially for vulnerable populations.
摘要：
随着患病率的增加，孤独和与隔离相关的结构是公共卫生问题。该保护伞的目的是整理和评分证据，以分析实际和主观的孤独感作为健康风险因素。在预期注册之后，在Pubmed进行了系统的搜索，Embase,Scopus,WebofSciences,psycoINFO和Cochrane图书馆，直到2023年8月。选择了评估实际和主观孤独感与不良健康结果之间关联的系统评价。使用AMSTAR-2工具评估偏倚风险。数据列表，综合叙述。共选择13篇系统评价(4篇纳入荟萃分析)。10篇综述的方法学质量极低(76.92%)，3篇综述的方法学质量极低(23.08%)。结果表明，孤独感与不良幸福感有关，并增加了不良身心健康的风险。现有数据表明，但不允许因果关系的确认。大多数孤独感似乎与心理和身体健康状况有关。应该建议采取预防策略，特别是弱势群体。
