Abstract：
Cancers are the product of evolutionary events, where molecular variation occurs and accumulates in tissues and tumors. Sequencing of this molecular variation informs not only which variants are driving tumorigenesis, but also the mechanisms behind what is fueling mutagenesis. Both of these details are crucial for preventing premature deaths due to cancer, whether it is by targeting the variants driving the cancer phenotype or by measures to prevent exogenous mutations from contributing to somatic evolution. Here, we review tools to determine both molecular signatures and cancer drivers, and avenues by which these metrics may be linked.
摘要：
癌症是进化事件的产物，分子变异发生并在组织和肿瘤中积累。这种分子变异的测序不仅告知哪些变异正在驱动肿瘤发生，而且是什么是助长诱变背后的机制。这两个细节对于防止癌症导致的过早死亡至关重要，无论是通过靶向驱动癌症表型的变体，还是通过防止外源突变促进体细胞进化的措施。这里,我们回顾了确定分子特征和癌症驱动因素的工具，以及可以链接这些指标的途径。
