Abstract：
Phage libraries are now amongst the most prominent approaches for the identification of high-affinity antibodies/peptides from billions of displayed phages in a specific library through the biopanning process. Due to its ability to discover potential therapeutic candidates that bind specifically to targets, phage display has gained considerable attention in targeted therapy. Using this approach, peptides with high-affinity and specificity can be identified for potential therapeutic or diagnostic use. Furthermore, phage libraries can be used to rapidly screen and identify novel antibodies to develop immunotherapeutics. The Food and Drug Administration (FDA) has approved several phage display-derived peptides and antibodies for the treatment of different diseases. In the current review, we provided a comprehensive insight into the role of phage display-derived peptides and antibodies in the treatment of different diseases including cancers, infectious diseases and neurological disorders. We also explored the applications of phage display in targeted drug delivery, gene therapy, and CAR T-cell.
摘要：
噬菌体文库现在是通过生物淘选过程从特定文库中的数十亿个展示的噬菌体中鉴定高亲和力抗体/肽的最突出的方法之一。由于其发现特异性结合靶标的潜在治疗候选物的能力，噬菌体展示在靶向治疗中获得了相当多的关注。使用这种方法，具有高亲和力和特异性的肽可以被鉴定用于潜在的治疗或诊断用途。此外，噬菌体文库可用于快速筛选和鉴定新型抗体以开发免疫治疗剂。美国食品和药物管理局(FDA)已经批准了几种噬菌体展示衍生的肽和抗体用于治疗不同的疾病。在当前的审查中，我们全面了解了噬菌体展示衍生肽和抗体在治疗包括癌症在内的不同疾病中的作用，传染病和神经系统疾病。我们还探索了噬菌体展示在靶向药物递送中的应用。基因治疗,和CAR-T细胞。
